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박선경(Seon Gyeong Bak),임형진(Hyung Jin Lim),원영선(Yeong-Seon Won),박은재(Eun Jae Park),오제훈(Je Hun Oh),김지은(Ji Eun Kim),이민지(Min Jee Lee),이소영(Soyoung Lee),이승웅(Seung Woong Lee),이승재(Seung Jae Lee),노문철(Mun Chual Rho 한국축산식품학회 2023 Food and Life Vol.2023 No.1
The skin is the largest organ that blocks invasion to the outside. Due to external stimuli, the skin barrier collapses and immune function abnormalities occur. This leads to skin diseases such as atopic dermatitis and psoriasis. Through this study, we attempted to develop a natural material that can be used for various dermatitis diseases. In this study, the gene expression of skin barrier-related proteins was confirmed using tumor necrosis factor-α/interferon-γ-stimulated HaCaT cells through real-time PCR. As a result, it was confirmed that the gene expression of skin barrier-related proteins and ceramide-related proteins was improved by the ABE-M. In this study, it was confirmed that the gene expression of filaggrin, involucrin, and loricrin, which are skin barrier-related proteins, was improved by ABE-M, and it was confirmed that the gene expression of the tight junction-related proteins, occludin and zonula occludens proteins-1, was also increased. As such, it is expected that ABE-M can be used as a material for skin inflammation such as atopic dermatitis.