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3′-[(18)F]Fluoro-3′-deoxythymidine의 합성과 9L glioma 세포를 이식한 래트에서의 체내동태에 관한 연구
심아영 ( Ah Young Shim ),문병석 ( Byung Seok Moon ),이태섭 ( Tae Sup Lee ),이교철 ( Kyo Chul Lee ),안광일 ( Gwang II An ),양승대 ( Seung Dae Yang ),유국현 ( Kook Hyun Yu ),천기정 ( Gi Jeong Cheon ),최창운 ( Chang Woon Choi ),임상 대한핵의학회 2006 핵의학 분자영상 Vol.40 No.5
MC - 50 싸이클로트론을 이용한 123I 제법 연구
이종두(Jong Doo Lee),서용섭(Yong Sup Suh),양승대(Seung Tae Yang),전권수(Kwon Soo Chun),한현수(Hyon Soo Han) 대한핵의학회 1991 핵의학 분자영상 Vol.25 No.2
N/A 123I, which is applied for the thyroid and other in vivo kinetic study, has a special role in life sciences. The 159 KeV r-ray from 123I is almost ideally appropriate for the current imaging instrurnentation. Its decay mode (electron capture) and short half-life (13.3 hr) reduced the burden of radiation dose to the patients, and its chemical property makes it easy to synthesize the labelling compounds. In this experiment, the production of 123I via the nuclear reaction 124Te(p,2n)123I with 28 MeV protons was sutdied. TeO, is used as a target material, because it has goad physical properties. The target was prepared with TeO, powder and was rnolten into a ellipsoidal cavity (a=14mm, b=10 mm, 270.8 mg/cm thick) of pure platinum. The irradiation was carried out in the external proton beam with incident energies range from 28 MeV to 22 MeV, and current was 30pA. The loss of TeO, target was significantly reduced by using 4-cooling system in irradiation. The dry distillation method was adopted for the separation of 123I from irradiated target, and when it was kept 5 minutes at 780C, its result was quantitative. The loss of the target material (TeO,) was below 0.2% for each production run and 'I from the dry distillation apparatus was captured with 0. 01 N NaOH in NaI form, then the pH of the solution was adjusted to 7.5-9.0 with HC1/NaOH. The Na123I solution was passed through 0.2pm membrane filter, and sterilized under high pressure and temperature for 30 minutes. The prodvction of 'I is acceptable for clinical application based on the quality of USP XXI.