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한국산 겨우살이 (Viscum album coloratum)로부터 정제된 렉틴 성분 KML-IIU의 예비 독성 및 일반 약리 시험
강태봉(Tae Bong Kang),윤택준(Taek Joon Yoon),김종배(Jong Bae Kim),송사유(Seong Kyu Song),이관희(Kwan Hee Lee),곽진환(Jin Hwan Kwak) 大韓藥學會 2001 약학회지 Vol.45 No.3
The study was carried out to evaluate the preliminary toxicity and general pharmacology of KML-IIU, a purified lectin com Korean Mistletoe (Visum album coloratum). KML-IIU was administered intravenously to ICR mice and Spargue-Dawley rats to investigate the acute toxicity. LD5O values in mice and rats were above 30mcg/kg. KML-IIU had no effects on the general behaviors, acetic acid induced writh- ing syndrome, pentobarbial induced sleeping time, pentylenetetrazole induced convulsion and the change of body temperature. In addition, KML-IIU did not show any effects on digestive system and blood coagulation system.