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한국인의 각종 질환에서 anti - HCV 의 검출 양상
박영민(Young Min Park),조철수(Chul Soo Cho),한남익(Nam Ick Hahn),김인식(In Sik Kim),김용수(Young Soo Kim),임계순(Gae Soon Lim),정진우(Jin Woo Chung),윤영석(Young Suk Yoon),이창돈(Chang Don Lee),김호연(Ho Yeon Kim),방병기(Byung Kee Ba 대한내과학회 1991 대한내과학회지 Vol.41 No.2
N/A We studied the prevalence of anti-HCV in 585 sera from various individuals using enzyme immunoassay (EIA, Abbott Laboraties, USA). The results were as follows: 1) Anti-HCV was detected in 16 (10.7%) out of 150 HBsAg positive liver diseases diagnosed by liver biopsy, consisting of none out of 10 acute viral hepatitis, 3 out of 15 chronic persistent hepatitis, 4 out of 50 chronic active hepatitis, 2 out of 32 liver cirrhosis, and 7 out of 43 hepatocellular carcinoma. 2) Anti-HCV was detected in 43 (45.3%) out of 95 HBsAg negative liver diseases diagnosed by liver biopsy, consisting of 5 out of 8 acute viral hepatitis, 2 out of 10 chronic persistent hepatitis, 17 out of 30 chronic active hepatitis, 4 out of 15 liver cirrhosis, and 15 out of 32 hepatocellular carcinoma. 3) Anti-HCV was detected in 22 (38.6%) out of 57 hemodialysis patients, in 3 (6.7%) out of 45 Kidney transplants, in 2 (11.1%) out of 18 fatty liver diagnosed by liver biopsy, in 2 (1.3%) out of 150 healthy blood donors, and none out of 40 healthy volunteers, 4) Anti-HCV was detected in 6 (31.6%) out of 19 rheumatoid arthritis and 6 (54.5%) out of 11 systemic lupus erythematosis. 5) There were familial clusters of chronic liver diseases in 4.7% of the patients with HRsAg negative/ anti-HCV positive chronic liver diseases and in 19.4% of the patients with HBsAg positive/anti-HCV negative liver diseases. 6) The incidence of anti-HCV within HBsAg positive liver diseases was higher in HBsAg negative patients (17.6%) than in HBeAg positive patients (10.3%). 7) In the hemodialysis patients, the number of hemodialysis was significantly higher in anti-HCV positive patients than in anti-HCV negative patients (p<0.009), but the number of blood transfusions didn't indicate a difference between anti-HCV positive and negative patients. We concluded that 1) HCV might be an important cause of various types of HBsAg negative liver diseases, 2) intrafamilial transmission of HCV might be much less common than of HBV, 3) coinfections of both HCV and HBV might be relatively common, 4) long duration of hemodialysis might be related to the increment of incidence of anti-HCV in hemodialysis units, and 5) the high frequency of false-positive anti-HCV in autoimmune disorders without evidence of liver diseases might limit the use of the current anti-HCV tests.
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