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김주연,정하연,반주연,유재국,배기환,성연희,Kim, Joo-Youn,Jeong, Ha-Yeon,Ban, Ju-Yeon,Yoo, Jae-Kuk,Bae, Ki-Hwan,Seong, Yeon-Hee 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.6
The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.
김주연,주현수,반주연,송경식,성연희,Kim, Joo-Youn,Ju, Hyun-Soo,Ban, Ju-Yeon,Song, Kyung-Sik,Seong, Yeon-Hee The Korean Society of Medicinal Crop Science 2008 한국약용작물학회지 Vol.16 No.6
Moutan cortex, the root bark of Paeonia suffruticosa Andrews (Paeoniaceae), has pharmacological effects such as anti-inflammatory, antiallergic, analgesic and antioxidant activities. We investigated a methanol extract of Moutan cortex for neuroprotective effects on neurotoxicity induced by amyloid ${\beta}$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons. Exposure of cultured cortical neurons to $10\;{\mu}M\;A{\beta}$ (25-35) for 24 h induced neuronal apoptotic death. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced neuronal cell death at 30 and $50\;{\mu}g/m{\ell}$, which was measured by a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining. Moutan cortex inhibited $10\;{\mu}M\;A{\beta}$ (25-35)-induced elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) which were measured by fluorescent dyes. Moutan cortex also inhibited glutamate release into medium induced by $10\;{\mu}M\;A{\beta}$ (25-35), which was measured by HPLC. These results suggest that Moutan cortex prevents $A{\beta}$ (25-35)-induced neuronal cell damage by interfering with the increase of $[Ca^{2+}]_i$, and then inhibiting glutamate release and ROS generation. Moutan cortex may have a therapeutic role in preventing the progression of Alzheimer's disease.
유기인제 중독의 복합예방제로서의 Procyclidine과 Physostigmine의 일반약리작용
이선애(Sun Ae Lee),조순옥(Soon Ock Cho),이보영(Bo Young Lee),반주연(Ju Yeon Ban),조영(Young Cho),허경행(Gyeung-Haeng Hur),김왕수(Wang-Soo Kim),김지천(Jee-Cheon Kim),김윤배(Yun-Bae Kim),성연희(Yeon Hee Seong) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
General pharmacological properties of procyclidine and physostigmine, as a combinational prophylactic regimen for organophosphate poisoning, were investigated in experimental animals and in vitro test system. Procyclidine and physostigmine were administerd by subcutaneous injection or miniosmotic pumps for sustained release. Procyclidine had no effects on general behavior, spontaneous motor activity, pentobarbital sleeping time, motor coordination and normal body temperature at the doses of less than 30 ㎎/㎏ or 1728 ㎍/㎏/hr. Gastric secretion and intestinal motility in rats were not influenced by the sustained release of procyclidine at dose of 1296 ㎍/㎏/hr. Procyclidine up to 40 ㎎/㎏ did not change the mean arterial blood pressure and heart rate in conscious rats. Procyclidine had no effect on the respiratory rate at the same doses when given to anesthetized rats. In in vitro experiments, procyclidine at the concentration of more than 0.1 and 1 ㎎/ℓ showed significant inhibitory action on the acetylcholine-and histamine-induced contractions, respectively, in the isolated ileum of guinea-pig. In the isolated guinea-pig tracheal muscle, procyclidine did not affect the histamine-induced contractions at the dose of 5 ㎎/ℓ, but showed partial inhibition on the acetylcholine-induced contractions at the doses of 3 and 5 ㎎/ℓ. Physostigmine at the concentration of 0.05 ㎎/㎏ or 36 ㎍/㎏/hr neither produced significant change of the normal physiological activity of rats, nor completely recover the inhibitory effect of procyclidine on the gastrointestinal tract. Based on these results, it was concluded that procyclidine and physostigmine did not induce marked adverse effects in experimental animals except the significant inhibitory effect on the gastrointestinal system.