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- 저자 : 박철신 ( Park Cheol Sin ) (검색결과 1 건)
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이명극 ( Lee Myeong Geug ),강원권 ( Kang Won Gwon ),김민범 ( Kim Min Beom ),박철신 ( Park Cheol Sin ),이헌영 ( Lee Heon Yeong ),김삼용 ( Kim Sam Yong ),이복희 ( Lee Bog Hui ) 대한내과학회 1990 대한내과학회지 Vol.38 No.6
N/A To investigate the B-cell function in patients with chronic liver diseases, a peripheral blood T-cell subset, a delayed type skin reaction, serum levels of IgG, IgA, IgM and in vitro production of IgA, IgG were studied in patients with chronic liver diseases(10 cases of chronic hepatitis, 12 cases of liver cirrhosis). The results were as follows: 1) The percentage of peripheral blood suppressor T-cell(CD8 positive) decreased in patients with chronic hepatitis(p<0.05). 2) The results of delayed type skin reaction with CMI test showed no difference between normal subjects and patients with chronic liver diseases. 3) Serum IgG, IgA and IgM levels increased in patients with chronic hepatitis and in patients with liver cirrhosis(p<0.05). Serum IgA levels in patients with liver cirrhosis showed the most prominent increase(330% of control). 4) Unstimulated in vitro IgA production from peripheral blood mononuclear cell lymphocytes was higher in patients with liver cirrhosis(p<0.05). IgA production stimulated with pokeweed mitogen was not different from that of the normal control subjects. IgG production stimulated with pokeweed mitogen was lower in patients with liver cirrhosis(n=5)(p<0.05, Wilcoxon rank sum test). The results of the present study indicate that there is no major defect in cellular immunity in patients with chronic liver diseases and that the B cells in patients with chronic liver disease are polyclonally activated in vivo. In patients with liver cirrhosis, the IgA-producing B cells seem predominently activated in comparison with the IgG-or IgM-producing B-cells.
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