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- 저자 : 박주홍(Joo Hung Park) (검색결과 2 건)
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한국산 도롱뇽 ( Hynobius leechii ) 의 농경지에서의 배 발생 이상과 살균제 Benomyl 의 독성효과
최영주(Yeoung Ju Choi),윤춘식(Chun Sik Yoon),박주홍(Joo Hung Park),진정효(Jung Hyo Jin),정선우(Seon Woo Cheong) 한국하천호수학회 2002 생태와 환경 Vol.35 No.3
A numerical variation and abnormalities were studied on egg bags and embryos of Korean salamander, Hynobius leechii from agricultural habitat. The teratogenic and toxic effects of fungicide benomyl were also investigated with early embryos from non-agricultural habitat. We collected 144 egg bags from agricultural region, and 3418 of early embryos were contained. The lengths of egg bags were varied from 10 to 23㎝ and the most frequent length was 19㎝. The number of embryos was varied from7 to 43, and the most frequent range was 22 to 26. Spontaneous abnormalities were occurred in 406 embryos among 116 egg bags, and 24 kinds of external abnormalities were found. Individuals showing severe external defect were histologically studied and they showed optic dyspalsia, thyroid carcinoma, somatic muscular dysplasia, partial biaxial structure, decrease of red blood cells in the heart, cephalic degeneration and intestinal dysplasia. 385 embryos from non-agricultural region were exposed to 200nM∼1μM of benomyl at blastula or gastrula for 12 days. All embryo were dead in the concentration of 1μM(LD_100) and 75% of embryos were dead in 800 nM of benomyl. Specific effect due to benomyl was acrania or cephalic dysplasia and this result suggests that the benomyl inhibit strongly to the development of neural tissue. These abnormal developments may be caused by antimitotic action, inhibition of tubulin complex, destruction of microtubule, inhibitions of neurulation and closing of neural fold, and by the inhibition of the movement of neural crest cells.
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정신분열증의 가용성 인터류킨-2 수용체 함량에 대한 연구
남세희,김임,박주홍 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.5
Objects : This study was designed to compare with the levels of SIL-2R in schizophrenic patients and normal controls as a evidence of immune activation related to autoimmunity. Methods : The subjects were 76 patients with schizophrenia diagnosed according to DSM-Ⅲ-R and they were divide into two groups. 38 chronic schizophrenic patients had been treated with antipsychotic drug for at least 6 months before this study. 40 healthy volunteers who had been worked in PMC(Presbyterian Medical Center) served as a control group. The blood samples were drawn from three groups and their serum were separated from blood and then serum IL-2R concentration were determined by Interleukin-2 receptor ELISA kit. Results : Mean SIL-2R levels were significantly elevated in medicated and unmedicated schizophrenic patients than normal controls(p< .0025). But, there was no significant difference in the mean SIL-2R levels for medicated and unmedicated schizophrenic patients. SIL-2R levels may be not related to age, gender and duration of illness in schizophrenic patients. Conclusion : These findings add to the weight of evidence suggesting that autoimmunity may play a role in the pathogenesis of some schizophrenics.
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