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RISS 인기검색어
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- 저자 : 박상철(Sang Chyl Park) (검색결과 1 건)
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간장 ( 肝臟 ) 및 담도 ( 膽道 ) : 쥐의 간경변증에서 간재생에 대한 아미노산 주입의 효과
이건욱(Kuhn Uk Lee),김영덕(Young Duk Kim),노동영(Dong Young Noh),박상철(Sang Chyl Park) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1
N/A The effects of amino acid administration on liver regeneration after partial hepatectomy were examined in 48 male Wistar Strain rats with cirrhosis. Cirrhosis was developed by pret#reatment of phenobarbiturates and intermittent oral administration of carbon tetrachloride. The rats were divided into three groups, each group of which was subjected to 2/3 hepatectomy. After hepatectomy, Solution A (10% D/W) was adminis- trated to group A, Solution B (10 % D/W+ 3 % AA 22% BCAA) to group B and Solution C (10 % D/W+ 3 % AA-35% BCAA) to group C. Twenty four hours after hepatectomy, the plasma levels of amino acids and the amount of each group was compared with each other. The molar ratio of BCAA/AAA of each group was; preoperative ratio (2.37 +- 0.29, Mean+SEM), group-A (1.06 +- 0.05), group-C (6.24 +- 0.72). The value of D.P.M./mgDNA was; group A (10829 +-2460, Mean+SEM), group B (6442 +- 883), group C (141841 +- 26171). In conclusion, it was considered that administration of BCAA-enriched solution into rats with cirrhosis, which was tailored to normalize the deranged patterns of plasma amino acids levels, accelerated the liver regeneration of remaining cirrhotic liver(p<0.05).
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