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김여진 ( Yun Jin Kim ),김재효 ( Jay Hyo Kim ),마빙 ( Cheng Ma ),심매홍 ( Mei Hong Shen ),이충인 ( Zhong Ren Li ),손인철 ( In Chul Sohn ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.2
Objectives: We investigated the effect of electroacupuncture on epileptic rat model and its underlying mechanisms on suppression of the epilepsy. Methods: It was used pentylenetetrazol (35∼40 mg/kg. i.p) induced epileptic rat model and square wave electrical stimulations (5 mA, 5, 40 or 80 Hz frequency) was applied to acupoints on "Dazhui" and "Taichong" for 30min. Results: Electroacupuncture suppressed spikes and slow waves of EEG due to the epileptic condition. Out of electroacupuncture, a high frequency of 80Hz had a better effect for suppress epileptic EEG wave. Conclusions: Electroacupuncture can markedly reduce the excitability of cerebral cortex and strengthen the inhibitory process, checking epilepsy wave. Some intrathalamic nuclei have a promoting or inhibiting effect on epileptic EEG wave. This experimental study we are proposed to Electro-acupuncture can suppression epileptic rat model and it`s scientific mechanisms.