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RISS 인기검색어
- 검색키워드
- 저자 : 김정수(Joung-Soo Kim) (검색결과 100 건)
- 무료
- 기관 내 무료
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Focus 5 (FS 5) : Biology of HPV in human skin & mucous membrane
김정수 ( Joung Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Human papillomaviruses (HPVs) are DNA tumor viruses that induce hyperproliferative lesions in cutaneous and mucosal epithelia. The most frequent manifestation of cutaneous HPV infection is the warts which is self-limiting epithelial proliferations. Recently, there is increasing evidence showing the involvement of cutaneous HPV types in the process of skin carcinogenesis. The HPV life cycle is subdivided into two stages, non-productive and productive stages according to the differentiation of the keratinocyte. Non-productive stages are establishment of the viral genome as a low copy number nuclear plasmid. Productive stages occur in the terminally differentiated layers of epithelium, as infected cells undergo their normal life cycle and a subset of daughter cells leave the basement membrane to stratify and differentiate. During this stage, HPV amplifies its genome to a higher copy number and expresses its late genes and produces viral progeny. When HPVs are associated with benign skin lesions, the viral genome replicates as an extrachromosomal episome separately from the host cell``s DNA. In contrast, in most malignant lesions, the viral DNA is integrated into the host cell chromosome. When integration occurs, a break in the viral genome occurs leading to loss of function of E1/E2 proteins. This in turn causes deregulation of E6 and E7 resulting in cellular transformation. The E6 and E7 genes of HPV are thought to play causative roles, since E6 promotes the degradation of p53 through its interaction with E6AP, an E3 ubiquitin ligase, whereas E7 binds to the retinoblastoma protein and disrupts its complex formation with E2F transcription factors. Also, recent molecular studies revealed a likely role for HPV infection in skin carcinogenesis as a co-factor in association with UV. The role of UV light in the process of skin carcinogenesis is widely accepted with possible mechanisms including mutation of p53 or other cell cycle-associated pathways and local or systemic immunosuppression. In this lecture, we will discuss about the biology of HPV in human skin and mucous membrane.
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Educational Lecture 1-2 (EL 1-2) : Phototesting
김정수 ( Joung Soo Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Phototesting is specialized tests which confirm the presence of an abnormal cutaneous reaction to light. It is also used to establish a diagnosis in patients with suspected photodermatoses and to determine threshold dose and wavelength dependence. For example, phototesting is used to confirm a diagnosis of solar urticaria, systemic phototoxicity, or photosensitivity in certain idiopathic photodermatoses, such as chronic actinic dermatitis. It can also help to characterize certain secondary photodermatoses induced by endogenous agents, such as erythropoietic protoporphyria or photosensitive forms of lupus erythematosus. The phototest procedure comprises three steps. First, the threshold dose for erythema response is determined by minimal erythema dose (MED) testing. To determine the MED, phototesting is conducted on the back, buttocks or inner aspect of the forearm. Small skin fields are irradiated with increasing ultraviolet (UV) doses. Step two is reproduction of photodermatosis by a provocation phototest procedure. Repeated irradiations are performed with polychromatic UVA and/or UVB on consecutive days to provoke the photodermatoses. Third is photopatch testing to identify photoallergy. It is patch testing with the addition of UV radiation to induce formation of the photoallergen. It is used to diagnose photoallergy and photocontact dermatitis. In advance of phototesting, the patients need to be informed of the risk of sensitization as recognized in routine patch testing and be aware of the possibility of strong provocation test results. The test should be performed on a part of the body that is generally not exposed to sunlight. Photopatch testing should not be performed when the dermatitis is active. In this lecture, we will discuss about the procedures and applications of the phototesting, focusing on the clinical usefulness.
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Educational Lecture 1-2 (EL 1-2) : Phototesting
김정수 ( Joung Soo Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Phototesting is specialized tests which confirm the presence of an abnormal cutaneous reaction to light. It is also used to establish a diagnosis in patients with suspected photodermatoses and to determine threshold dose and wavelength dependence. For example, phototesting is used to confirm a diagnosis of solar urticaria, systemic phototoxicity, or photosensitivity in certain idiopathic photodermatoses, such as chronic actinic dermatitis. It can also help to characterize certain secondary photodermatoses induced by endogenous agents, such as erythropoietic protoporphyria or photosensitive forms of lupus erythematosus. The phototest procedure comprises three steps. First, the threshold dose for erythema response is determined by minimal erythema dose (MED) testing. To determine the MED, phototesting is conducted on the back, buttocks or inner aspect of the forearm. Small skin fields are irradiated with increasing ultraviolet (UV) doses. Step two is reproduction of photodermatosis by a provocation phototest procedure. Repeated irradiations are performed with polychromatic UVA and/or UVB on consecutive days to provoke the photodermatoses. Third is photopatch testing to identify photoallergy.It is patch testing with the addition of UV radiation to induce formation of the photoallergen. It is used to diagnose photoallergy and photocontact dermatitis. In advance of phototesting, the patients need to be informed of the risk of sensitization as recognized in routine patch testing and be aware of the possibility of strong provocation test results. The test should be performed on a part of the body that is generally not exposed to sunlight. Photopatch testing should not be performed when the dermatitis is active. In this lecture, we will discuss about the procedures and applications of the phototesting, focusing on the clinical usefulness.
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김정수 ( Joung Soo Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Phototesting is specialized test which confirms the presence of an abnormal cutaneous reaction to light. It is also used to establish a diagnosis in patients with suspected photodermatoses such as polymorphic light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis and solar urticarial, and to determine threshold dose and wavelength dependence. The phototest procedure is composed of three steps. 1. Phototest: Determination of MED (Minimal erythema dose) - Confirm the presence of a photosensitivity disorder - Uninvolved skin of the patient`s back, abdomen or inner forearms is exposed to different doses of UVB (Ultraviolet B), UVA (Ultraviolet A) and visible monochromatic or broad-spectrum radiation. - The assessment of cutaneous response consists of immediate observation of possible urticarial lesions (for solar urticaria) and the MED reading performed 24hr later. - Most helpful for the diagnosis of immunologically mediated photodermatoses 2. Photoprovocation: Reproduction of photodermatosis by a provocation phototest procedure - Used to reproduce an eruption so that the morphology of the lesion can be examined in greater detail - Usually, 80% of the MED is used as the starting dose, and an increase of 10% to 20% is performed on consecutive days. - The test field should be larger than that used in phototesting, as photoprovocation sometimes induces separate papules that could be underestimated. 3. Photopatch testing: Photopatch testing is conducted to identify photoallergy - Used to evaluate patients with photoallergic contact dermatitis. - Two sets of photoallergen panels are placed on uninvolved sites of the skin, usually on the upper back. - One set is removed after 24hr and irradiated with UVA of 5-10 J/cm2. After 48 and 72hr, both sets of patch tests (the irradiated and nonirradiated sides) are evaluated for a positive reaction. Precautions - need to be informed of the risk of sensitization - should be performed on a part of the body that is generally not exposed to sunlight - should not be performed when the dermatitis is active.
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김정수 ( Joung Soo Kim ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2
Phototesting is specialized test which confirms the presence of an abnormal cutaneous reaction to light. It is also used to establish a diagnosis in patients with suspected photodermatoses such as polymorphic light eruption, actinic prurigo, hydroa vacciniforme, chronic actinic dermatitis and solar urticarial, and to determine threshold dose and wavelength dependence.
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