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갑상선 암 환자에서 131I 치료시 MIRD Schema에 의한 흡수선량의 평가
김장휘(Jang Hee Kim),임상무(Sang Moo Lim),홍성운(Sung Woon Hong),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),김기섭(Ki Sup Kim) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A Medicai Internal Radiation Dose(MIRD) schema was developed for calculating the absorbed dose from the administered radiopharmaceuticals. With the biological distribution data and the physical properties of the radionuclide we can estimate the absorbed dose by the MIRD schema. For the thyroid cancer patients received 131I therapy, the absorbed dose to the bone marrow is the limiting factor to the administered dose, and the duration of admission is determined by the retained activity in the whole body. To monitor the whole body radioactivity, we used Eberline Smart 200 system using ionization chamber as a detector. With the time activity curve of the whole body, total body residence time was obtained. From the ICRP publication 53, the residence times of the source organs, such as kidney, urinary bladder content and stomach, were, used to calculate the absorbed doses of the target organs, such as stomach, red marrow, b1adder wall and remaineder total body. In 8 thyroid cancer patients with 175 mci of 131I adminstered orally, the mean absorbed dose in the blader wall was 375.1 in the stomach 285.1, red marrow 25.4 and total body 22.4 rad respectively. For the monitoring of the large administered activity, this method seemed to be quite useful.
57 Co-BLM 을 이용한 종양진단 신티그라피에 관한 연구
이진오,김장휘,유용운 대한핵의학회 1987 핵의학 분자영상 Vol.21 No.1
Investigation with (57)^Co-Bleomycin in patients with the various cancers and in tumor bearing animals are descirbed. In the patients, (57)^Co-Bleomycin appears to be one of the useful tumor- seeking radiopharmaceuticals, and worth applicable to clinical uses. Labelled yield of (57)^Co-Bleo was about 97% by thin layer chromatography. The pyrogen free tests were performed to meet U.S.P. critical ranges. In clinical studies with 57Co-Bleo, 4 cases out of 5 patients with lung cancer., 2 cases among 3 thyroid cancer patients, and all 3 hepatoma patients showed positive tumor scans. The patients with stomach cancer, and the esophageal cancer showed false negative scintigraphy. A case with pulmonary tuberculosis showed a positive scan while liver abscess showed a negative picture. The merits of 57Co-Bleomycin scintigraphy seems to be its relatively high affinity to tumors and low radiation hazard in spite of long physical half life.
흰쥐 육종 180 에서 169Yb-Citrate 의 종양 친화성
이진오,홍성운,김장휘,임상무 대한핵의학회 1988 핵의학 분자영상 Vol.22 No.1
Tumor localizing properties of (67)^Ga citrate and (169)^Yb citrate were studies with sarcoma 180 bearing mice. To compare precisely the accumulation of (67)^Ga citrate and (169)^Yb citrate in tumor tissue itself, 67Ga and 169Yb were administered simultaneously as a mixture of same chemical form of citrate. The yield of (169)^Yb labeled citrated and the of radiopharmaceuticals purity was identified more than 90% by chromatography on silica gel plates. (67)^Ga and 169Yb were injected into mice and the mice were killed at 3, 24, and 48 hours following intraperitoneal injection of the radiopharmaceuticals. The retention value of (67)^Ga and (169)^Yb in tumor was similar but they differ from each other markedly in normal tissue distribution. (169)^Yb citrate is cleared up from blood more rapidly than (67)^Ga citrate, and a high tumor to blood ratio is achieved shortly after injection.