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태음조위탕(太陰調胃湯)의 항산화(抗酸化) 효능(效能)에 의한 간세포(肝細胞) 보호(保護) 효과(效果)에 관한 연구(硏究)
김만우,박성식,Kim, Man-woo,Park, Seong-sik 사상체질의학회 2001 사상체질의학회지 Vol.13 No.1
Effects of Taeumjowetang on Lipid Peroxidation by Free Radicals and Oxidative Damage of Hepatocytes by tert-Butyl Hydroperoxide. 1. Purpose The present study was carried out to evaluate the antioxidant effects of Taeumjowetang in vitro. 2. Methods In this study, antioxidant effects of TJT on lipid peroxidation were determined according to the method of TBA. (Abbreviation) TJT : Taeumjowetang, TBA : 2-thiobarbituric acid. 3. Results : 1) TJT inhibited markedly peroxidation of linoleic acid during the autoxidation. 2) TJT inhibited lipid peroxidation induced by hydroxyl radical derived from H2O2-Fe2+ in rat liver homogenate. 3) TJT showed 66% scavenging effect on DPPH radical. 4) TJT exhibited a 25% inhibitory effect on superoxide generation from xanthine-xan thine oxidase system. 5) To investigate the antioxidative effects of TJT on the hepatocytes, cultured normal rat liver cells(Ac2F) were prepared and incubated with or without TJT. After 16~18hr, cells placed in DMEM medium without serum, and then incubated with 1mM t-BHP for 2hr. Viable cells were detected by MTT assay. In this test, TJT protected the cell death induced by t-BHP and significantly increased cell viability in the normal rat liver cell. (Abbreviation) DPPH : ${\alpha},{\alpha}$-diphenyl-${\beta}$-picryl hydrazyl, DMEM : Dulbecco's Modified Eagle Medium, t-BHP : terr-butyl hydroperoxide, 4. Conclusion These results suggested that TJT might play a protective role in lipid peroxidation by free radicals.
위장관 ( 胃腸管 ) : 위궤양 환자에서 Omeprazole 반복 투여시 혈청 Gastrin과 Pepsinogen A치의 변화
김만우(Man Woo Kim),박찬국(Chan Gook Park),전용준(Yong Jun Jeon),신양수(Yang Su Shin),유병전(Byung Jeon Yuh),최성도(Sung Do Choi),서영환(Yong Hwan Suh),노상현(Sang Hyun Noh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4
N/A The fasting serum gasrin and pepsinogen A levels on oral Omeprazole treatment were observed in 17 patients of gastric ulcer diagnosed by gastrofiberscopy. The fasting serum gastrin and pepsinogen A levels 1 day prior to oral omeprazole treatment, during treatment (1st, 7th, 14th day) and fo]lowing 2 weeks treatment (1st, 7th, 15th day) were monitored respectively and compared each other. The results were as follows. 1) Serum gastrin and pepsinogen A levels during and following the treatment were significantly increased compared to basal gastrin and pepsinogen A levels before treatment each (p<0.01). 2) Serum gastrin levels following the 2 weeks treatment did not change significantly compared to that during treatment. 3) The relationship between the basal serum gastrin levels before treatment and the gasrin levels during the treatment showed positive correlation (r=0.414: p<0.01).