http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김덕한 ( Duk Han Kim ),강봉선 ( Bong Seon Kang ),조상현 ( Sang Hyun Cho ),이정덕 ( Jeong Deuk Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.7
Cutaneous leiomyoma is a rare, benign tumor of smooth-muscle fibers. Five types of cutaneous leiomyoma include multiple piloleiomyomas, solitary piloleiomyoma, solitary genital leiomyoma, solitary angioleiomyoma and leiomyoma with additional mesenchymal elements. Genital leiomyoma is uncommon, and leiomyomas of the nipple is a rare type of genital leiomyoma. We report a case of cutaneous leiomyoma presenting as a large nipple in a middle-aged woman. (Korean J Dermatol 2006;44(7):830~833)
김덕한,김인령,박봉수,안용우,정성희,Kim, Duk-Han,Kim, In-Ryoung,Park, Bong-Soo,Ahn, Yong-Woo,Jeong, Sung-Hee The Korean Academy of Orofacial Pain and Oral Medi 2013 Journal of Oral Medicine and Pain Vol.38 No.3
담즙산은 지방의 흡수와 콜레스테롤의 항상성을 조절하는 유전자의 전사에 관여하는 필수 콜레스테롤의 생성물이다. 담즙산 합성유도체인 HS-1200이 여러 가지 암세포에서 세포자멸사(apoptosis)를 유도한다는 것이 알려져 있다. 본 연구는 사람혀 편평세포암종세포(SCC25 cells)에서 담즙산 합성유도체인 HS-1200과 대표적인 항암제인 cisplatin의 병용처리 후 세포자멸사 증가효과가 있는지 알아보기 위해 수행하였다. HS-1200과 cisplatin의 병용처리가 단독처리에 비해서 효과적인 세포생존율 감소가 있는지 확인하기 위해서 MTT법을 시행하였고, 세포자멸사의 유도와 증가를 알기 위해서는 DNA 전기영동법, Hoechst 염색법, DNA hypoploidy법 을 사용하였다. 그리고 세포자멸사에 관계하는 단백질의 발현 변화와 세포내에서의 이동을 밝혀내기 위해서 Western blot 분석과 면역형광 염색법을 수행하였다. 더 나아가서 proteasome 활성도와 사립체막 전위 변화를 측정하였다. 본 연구에서는 HS-1200과 cisplatin을 병용처리한 SCC25 세포에서 핵의 농축, DNA분절, MMP와 proteasome 활성도의 감소, Bax의 증가와 Bcl-2의 감소, DNA양의 감소, cytochrome c의 세포질로의 유리, AIF와 DFF40(CAD)의 핵으로의 이동, caspase-9, caspase-7, caspase-3, PARP 그리고 DFF45(ICAD)의 활성화와 같은 다양한 세포자멸사 증거를 보였다. 반면에 상기 물질들에 단독처리 된 SCC25 세포에서는 세포자멸사 현상이 거의 없었다. 24시간 동안 $25{\mu}M$의 HS-1200, $4{\mu}g/ml$의 cisplatin 을 각기 단독처리 한 결과에서는 세포자멸사를 거의 유도하지 못했으나, 병용처리한 결과에는 아주 탁월하고 명확한 세포자멸사의 유도를 보였다. 그러므로 본 실험결과는 HS-1200과 cisplatin 의 병용요법이 사람구강편평세포암종 환자를 위해 새로운 치료전략으로서의 가능성을 보여준다고 생각한다. Bile acids are polar derivatives of cholesterol essential for the absorption of dietary lipids and regulate the transcription of genes that control cholesterol homeostasis. Recently it have been identified the synthetic chenodeoxycholic acid (CDCA) derivatives HS-1200 and cisplatin showed apoptisis-inducing activity on various cancer cells in vivo and in vitro. This study was undertaken to investigate the synergistic apoptotic effect of co-treatment with HS-1200 and cisplatin on human tongue squamous cell carcinoma cells (SCC25 cells). To investigate whether the co-treatment with HS-1200 and cisplatin compared to each single treatment efficiently reduces the viability of SCC25 cells, MTT assay was conducted. The induction and augmentation of apoptosis were confirmed by DNA electrophoresis, Hoechst staining and an analysis DNA hypoploidy. Westen blot analysis and immunofluorescent staining were also performed to evaluate the expression levels and the translocation of apoptosis-related proteins following this co-treatment. Furthermore, proteasome activity and mitochondrial membrane potential (MMP) change were also assayed. In this study, co-treatment with HS-1200 and cisplatin on SCC25 cells showed several lines of apoptotic manifestation such as nuclear condensations, DNA fragmentation, reduction of MMP and proteasome activity, the increase of Bax and the decrease of Bcl-2, decrease of DNA content, the release of cytochrome c into cytosol, translocation of AIF and DFF40 (CAD) onto nuclei, and activation of caspase-9, caspase-7, caspase-3, PARP and DFF45 (ICAD) whereas each single treated SCC25 cells did not show these patterns. Although the single treatment of $25{\mu}M$ HS-1200 and $4{\mu}g/ml$ cisplatin for 24 h did not induce apoptosis, the co-treatment of these reagents prominently induced apoptosis. Therefore our data provide the possibility that the combination therapy with HS-1200 and cisplatin could be considered as a novel therapeutic strategy for human squamous cell carcinoma.
사고조사위원회 보고서를 통해서 본 사업장 원하청 구조와 안전관리에 대한 연구(발전업, 조선업종을 중심으로)
김덕한(Duk Han Kim),최성륜(Sung Ryun Choi),박소영(So Young Park),김동리(Dong Ri Kim),천영우(Young Woo Chon) 한국위험물학회 2020 한국위험물학회지 Vol.8 No.1
According to the "Industrial Accidents Integrated Management System for Contractor and Subcontractor," which was first introduced in 2018, the list of contractor with a high proportion of deaths at subcontractors is being announced. This can be interpreted as acknowledging that the industrial accident that occurs is not merely an worker"s carelessness, but implies the possibility of an accident occurring in the characteristics of the business itself operated by the workplace. This is a matter of industrial structure and it is necessary to look at the actual accident of the contractor and the subcontractor. The problem of shifting risks arising from the contractor"s contracting to subcontractors is increasing not only domestically but all over the world. Therefore, in this study, each accident was analyzed because it was determined that there would be many cases of accidents involving shipbuilding and power plants, where many accidents occur, in the contractor and subcontractor structure. In addition, the revised Industrial Safety and Health Act, which will go into effect on Jan. 16, 2021, will confirm whether it can solve the risk problems caused by the contractor and subcontractor, and suggest a direction to look into subcontracting issues in the Industrial Safety and Health Act through cases in other countries.
위해관리계획서 작성 사업장 간 ‘비상대응 정보공유체계’ 구축에 관한 연구
김덕한(Duk Han Kim),최성륜(Sung Ryun Choi),천영우(Young Woo Chon),이선민(Sun Min Lee),허화진(Hwa Jin Heo) 한국위험물학회 2020 한국위험물학회지 Vol.8 No.1
Currently, high-risk business sites that handle accident-preparatory materials more than the designated quantity must submit a risk management plan. Through this, the company manages the risk of spreading out of business sites due to chemical handling. However, as the number of chemical businesses in Korea increases day by day, the frequency of accidents and their damage are only increasing. At this time, initial response is important to reduce accident damage, but in small and medium-sized businesses, initial response is not good. To solve this problem, the emergency response information sharing system in the project site management plan should be established to jointly respond to accidents. In this study, we derived information that can be shared in establishing a system for sharing emergency response information among businesses. It also provided guidelines for improving emergency response information and establishing a system for sharing emergency response information among businesses.
Squint SAR 영상 내 목표물 분산전력패턴 분석기법
황지환(Ji-Hwan Hwang),김덕진(Duk-Jin Kim),이승철(Seung-Chul Lee),한승훈(Seung-Hoon Han),조재형(Jae-Hyoung Cho),문효이(Hyoi Moon) 한국전자파학회 2018 한국전자파학회논문지 Vol.29 No.9
본 논문에서는 FMCW(frequency modulated continuous wave) 신호기반 SAR 시스템의 스퀸트 각도(squint angle) 설정에 따른 복원영상 내 목표물 분산전력패턴 변화를 예측하기 위한 분석기법에 대해 설명한다. SAR 복원영상 내 목표물 분산전력패턴은 지면에 투영된 전파진행방향과 합성개구면과 스퀸트 각도가 이루는 방위방향에 따라 일정한 방향으로 변형된 특성을 갖게 되며, 이와 같은 특성변화를 3차원 SAR 기하구조 내에서 분석한다. 스퀸트 설정각도에 따라 변형된 목표물 분산전력패턴은 FMCW 신호모델과 back-projection 알고리즘을 기반으로 한 모의실험을 통해 그 분석결과를 검증한다. 또한, 변형된 분산전력패턴의 예측결과는 SAR 기하구조와 스퀸트 설정각도를 변수로 정리된다. This paper presents an analysis technique for estimating the properties of a target’s power-spill patterns observed in reconstructed SAR images, which in turn depend on the setup squint angle of the FMCW signal-based SAR system. The target responses observed in the reconstructed SAR images were affected by the range-direction and azimuth-direction of a wave projected on the ground, and the obtained results were analyzed by applying three-dimensional squinted SAR geometry. Furthermore, the rotation patterns were verified through simulations based on the FMCW signal model and back-projection algorithm. This paper summarizes the obtained evaluation results as a function of SAR geometry and squint angle.