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한경숙(Kyung Sook Han),경난호(Nan Ho Kyung),박이갑(Lee Gap Park) 대한내과학회 1988 대한내과학회지 Vol.35 No.5
N/A Magnesium is the second most abundant intracellular cation and is an essential cofactor in the metabolism of carbohydrates. The authors measured serum glucose and magnesium concentrations during intravenous glucose tolerance tests, and fasting plasma insulin, serum magnesium and HbA₁C levels in 61 diabetics for the evaluation of abnormal metabolism of magnesium in diabetes mellitus. The results obtained were as follows: 1) Fasting serum magnesium levels were lower in diabetics (0.95±0.11 mmol/1) than in normal controls(1.00±0.13mmol/1) (p<0.05). 2) In diabetics, fasting serum magnesium levels were inversely related to HbA₁C levels (r=-0.2606, p<0.05), 3) In diabetics, the KG constant for the disposal rate of glucose during the intravenous glucose tolerance test was directly related to fasting serum magnesium levels (r=0.2516, p<0,05). 4) In diabetics, fasting serum magnesium levels were not significantly related to fasting plasma insulin levels and the insulin resistance factor.
양성 단일 갑상선결절의 L - Thyroxine 억제요법
성연아(Yeon Ah Sung),경난호(Nan Ho Kyung) 대한내과학회 1991 대한내과학회지 Vol.41 No.6
N/A Clinically apparent thyroid nodule is a very common disease in adults and patients with benign solitary thyroid nodules on aspiration biopsy often treated nonsurgically. We investigated the efficacy of thyroxine sup pressive therapy and the hormonal characteristics during thyroxine therapy to findout whether such measurements could be used to determine the effectiveness of this therapy in patients with benign solitary thyroid nodule proved by aspiration biopsy. Fifty-two patients were randomized to receive the L-thyroxine treatment (group I, n=28) or a placebo (group II, n=24). High resolution ultrasonography was used to measure the size of the nodules before and after treatment. The dose of thyroxine was adjusted until the TRH test was negative. Patients were followed at 3- month intervals. The results were as follows: 1) Twelve (42.9%) out of 28 Group I patients after adequate TSH suppression and 6 (25.0%) out of 24 Group II patients after 3 months had a reduction of nodule size, and before-to after nodule volume ratios were not significantly different between the Group I and Group II patients. 2) In 15-month follow-up periods, the nodule volume decrement was larger in Group I than Group II, but there was no statistical significance. 3) In the responders among Group I patients, the before-to-after therapy ratio of thyroglobulin was significantly higher than in the nonresponder. 4) In the responders among the Group I patients, the before-to-after therapy ratio of the nodule volume was not related to the pretreatment nodule size or thyroid hormone and thyroglobulin levels. Thus we concluded that an adequate suppressive dose of L-thyroxin did not alter the natural course of the benign solitrry thyroid nodules, and serum thyroglobulin measurements may prove a useful indicator of the efficacy of thyroxine therapy.