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殷載淳,鄭甲基,梁在憲,權鎭,吳贊鎬,全焄 又石大學校 1995 論文集 Vol.17 No.-
The purpose of this research was to investigate effect of water-soluble protein of Trichosanthes kirillowii(TKP) on the proliferation of human tumor cells. TKP inhibited the proliferation of HeLa cells and KHOS-NP cells. The inhibitory activity of doxorubicin on HeLa cells and its of mitomycin C on KHOS-NP cells were increased by the combination of TKP. TKP did not affect on the proliferation of Balb/c 3T3 cells, but inhibited the proliferation of mouse spleen cells and human lymphocyte at 1 ㎍/ml. These results suggest that TKP bas the cytotoxicity on HeLa and KHOS-NP cells, and increase the cytotoxicity of doxorubicin or mitomycin C.