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- 저자 : ( Zhen Fa Qi ) (검색결과 3 건)
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( Zhen Fa Qi ) 한국세무회계학회 2007 발표논문집 Vol.21 No.-
In the age of knowledge economy, human society is undergoing a great revolution from industry economy to knowledge economy, and human resources management has becomean important part of operational strategy of enterprises. Human resources possessing knowledge are the first important resources. The paper has put forward that human resources now available are the major force and the practical choice of sustainable development of enterprises. Based on the analysis of the current talents resources in enterprises and the characteristic of talents in enterprises under the conditions of knowledge economy, the paper has also come up with countermeasures that enterprises keeps and make good use of talents, namely, to develop pay-for-performance policies, to intensify efforts to inspire talents, to create conditions to keep talents by causes and to set up cause platform for talents, to accelerate the renewal of knowledge of the existing talents, strengthen talents` exercise and cultivation in practices, to retain talents by emotion, and to adopt open policies of talents, set up the new mechanism of talents management. The study is conducive to guide enterprises to retain, foster, make good use of talents resources, and also is favorable to realize sustainable development of enterprises.
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Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer
Sun, Zhen-Qiang,Wang, Hai-Jiang,Zhao, Ze-Liang,Wang, Qi-San,Fan, Chuan-Wen,Kureshi, Kureshi,Fang, Fa Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Background: Significance of HPV infection and genic mutation of APC and K-ras in rectal cancer has been investigated but not clarified. The objective of our study was to investigate these parameters in patients with rectal cancer to analyze correlations with biological behaviour, to determine relationships among the three, and also to demonstrate survival prognosis effects. Methods: From December 2007 to September 2008, 75 rectal cancer cases confirmed by histopathology in the Tumor Hospital of Xinjiang Medical University were enrolled. The control group consisted of normal rectal mucous membrane taken simultaneously, a least 10 cm distant from the carcinoma fringe. HPV DNA, the MCR of APC and exon-1 of K-ras were detected by PCR and PCR-SSCP. All results were analyzed in relation to clinical pathological material, using chi-square and correlation analysis via SPSS.13 and Fisher's Exact Probability via STATA. 9.0. All 75 patients were followed up for survival analysis using Kaplan-Meier and Log-rank tests. Results: 55 out of 75 cases demonstrated gene HPV L1 while it was notdetected in normal rectal mucosa tissue. HPV infection was correlated with age and lymphatic metastasis (P<0.05) but not other characteristics, such as ethnicity, tumor size, histological type, tumor type, Duke's stage and infiltration depth. Some 43 cases exhibited APC genic mutation (57.3%) and 34 K-ras genic mutation (45.3%). APC genic mutation was correlated with gender(P<0.05), but not age, histological type, infiltration depth, lymphatic metastasis and Duke's stage. In 55 cases of rectal cancer with HPV infection, there were 31 cases with genic mutation of APC (56.4%) and 24 with genic mutation of K-ras (43.6%). For the 20 cases of rectal cancer with non-HPV infection, the figures were 12 cases (60%) and 10 (50.0%), respectively, with no significant relation. Survival analysis showed no statistical significance for K-ras genic mutation, APC genic mutation or HPV infection (P>0.05). However, the survival time of the patients with HPV infection was a little shorter than in cases without HPV infection. Conclusions: Our results suggest that HPV infection might be an important factor to bring about malignant phenotype of rectal cancer and influence prognosis. Genic mutation of APC and K-ras might be common early molecular events of rectal cancer, but without prognostic effects on medium-term or early stage patients with rectal cancer.
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