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RISS 인기검색어
- 검색키워드
- 저자 : ( Sudimna Dahal ) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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PE-163: Association Liver Enzymes with Blood Pressure in Diabetic Patients
( Shrestha Rojeet ),( Shrestha Nirajan ),( Bhatt Nirmal Prasad ),( Dahal Sudimna ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Gamma-glutamytransferase (GGT) is routinely used laboratory investigation for liver damage and alcohol consumption. Serum GGT concentration is determined by body fat content, lipid and glucose levels, alcohol consumption and various medications. Several lines of evidence show that serum GGT is associated with cardiovascular and all-case mortality. It is also a marker of oxidative stress. Although serum GGT is associated with hypertension, the correlation between GGT and blood pressure has not been well established. The aim of the present study was to investigate the association between serum GGT and blood pressure in type 2 diabetic patients (T2DM). Methods: A total number of 105 patients with T2DM, who attended Nepal Medical College Teaching Hospital, Kathmandu, Nepal, were recruited for the study. There were 39 males (mean age: 56.6±5.2 years) and 66 females (mean age: 49.6±6.3). The patients with history of liver disease and alcohol intake were excluded from the study. After basic anthropometric measurement, fasting venous blood was collected and subjected for the estimation of liver enzymes. All data were expressed as mean± SD. p-values less than 0.05 were considered as statistically significant. Results: Although serum ALT and AST levels were significantly elevated within the normal range in T2DM compared to control, they are not correlated with systolic blood pressure (SBP) (r= 0.07 and 0.128, respectively) and diastolic blood pressure (DBP) (r= 0.08 and 0.02, respectively) in both men and women. However, serum GGT levels within their normal range were positively correlated with SBP (r=0.4, p<0.01) and DBP (r=0.275, p<0.05) in women. Interestingly, neither of these liver enzymes was correlated with blood pressure among men diabetic patients. Conclusions: These findings suggest that GGT may be linked with blood pressure balance in women and evaluating the levels of GGT could help in the monitoring of hypertension in diabetic individuals.
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( Nirajan Shrestha ),( Nirmal Prasad Bhatt ),( Sudimna Dahal ),( Rojeet Shrestha ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Serum gamma-glutamyltranspeptidase ( GGT), a marker of liver injury, alcohol consumption, and oxidative stress, has been shown to be associated with obesity and diabetes mellitus. Obese individuals with higher GGT are associated with complications in type 2 diabetic patients. There is evidence that waist circumference (WC) measured obesity more accurately than body mass index (BMI). In the present study, we aimed to evaluate association of GGT with WC and BMI in diabetic subjects. Methods: The study subjects were 105 type 2 diabetic patients (39 men and 66 women), who attended outpatient department of Nepal Medical College Teaching Hospital, Kathmandu, Nepal. The patients with the history of alcohol intake and liver disease were excluded from the study. Anthropometric measurement was taken and venous blood was collected for biochemical analysis. Statistical analysis was done using SPSS 16.0. The p-values less than 0.05 were considered as significant. Results: The serum GGT levels were positively correlated with blood sugar levels in diabetic subjects. Similarly, GGT levels were positively associated with WC (r=0.269, p<0.05) in women diabetic patients. However, no such correlation was observed in men diabetic subjects (r=0.14). Also, there was no correlation between serum GGT levels and BMI (r=0.03), suggesting that regional fat distribution in type 2 diabetes is associated with the increased levels of serum GGT. Conclusions: In conclusion, WC, not the BMI, is correlated with serum GGT levels in women with type 2 diabetics. Hence, it is important to evaluate central obesity and GGT in patients with diabetes mellitus.
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Hepatic Association with Increased ALT and GGT in Type 2 Diabetic Patients
( Nirmal Prasad Bhatt ),( Nirajan Shrestha ),( Sudimna Dahal ),( Rojeet Shrestha ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Diabetes mellitus (DM) has been associated with liver dysfunction and dyslipidemia, is a leading cause of global mortality, inducing various secondary complications, such as coronary heart disease, neuropathy and chronic kidney disease. DM is associated with non-alcoholic fatty liver disease (NAFLD), including its severe form, non-alcoholic steatohepatitis. NAFLD among diabetic patients in western countries is highly prevalent. However, there is a paucity of data showing such an association in Nepalese patients with DM. Thus, the current study was conducted for a better understanding of liver dysfunction in Nepalese patients with type 2 diabetes mellitus (T2DM). Methods: We conducted a prospective study to determine if any correlation exists between serum liver enzymes in T2DM and different confounding factors. One hundred and five patients (male:female= 0.6) with a median age of 52±1.09 years, newly diagnosed as having T2DM, were recruited from the outpatient department of tertiary hospital during one year. Results: We observed a marginal, yet statistically significant, increase of serum alanine transaminase and γ-glutamyl in the diabetic patients compared to healthy controls. However, elevation of serum AST was statistically insignificant. Conclusions: Elevation of the liver enzymes, ALT and GGT, within the normal range in T2DM may indicate initiation of pathological processes in the liver. Hence, regular monitoring of liver function is advantageous to prevent advanced liver injury in T2DM.
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