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- 저자 : ( Sudimna Daha ) (검색결과 1 건)
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( Nirmal Prasad Bhatt ),( Nirajan Shrestha ),( Sudimna Daha ),( Rojeet Shrestha ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Alanine aminotransferase ( ALT) and aspartate aminotransferase AST) are commonly used markers of liver-disorders. Non-alcoholic fatty liver disease (NAFLD) is associated with lipid abnormalities and type 2 Diabetes. Previous studies have suggested elevation in levels of ALT and AST which may serve as markers for NAFLD. However, correlation of liver enzymes and lipid profile has not been well established. Hence, current study was performed to observe the association between aminotransferases and HDL-C in type-2 diabetic patients. Methods: The study was carried out in Department of Pathology, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal. A total of 103 type 2 diabetic patients, 41 males (mean age: 55.9±13.4) and 62 females (mean age: 49.9±10.6) were included in this study. Patient’s anthropometric measurements were performed before collecting the fasting blood for aminotransferases and lipid profile analysis. The results were shown as mean ± SD. P-values less than 0.05 were considered as statistically significant. Results: In the present study, serum ALT and AST levels were correlated with fasting HDL (r= -0.419, P < 0.05 and r= -0.354, P < 0.05 respectively) in women with type 2 diabetes. However, there was no such correlation among these parameters in men diabetic patients. Furthermore, there was no correlation between aminotransferase and fasting TC, TG and LDL levels. Conclusions: This finding suggests the correlation between aminotransferase and FHDL in diabetic patients. Hence, measurement of aminotransferase and lipid profile has clinical significance in diabetic patients.
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