http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Srividhya Raghavan ) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
( Hiteshi Dhami-shah ),( Rama Vaidya ),( Shobha Udipi ),( Srividhya Raghavan ),( Shiny Abhijit ),( Viswanathan Mohan ),( Muthuswamy Balasubramanyam ),( Ashok Vaidya ) 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.1
Background/Aims: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could drive the development of potential therapies for Nonalcoholic fatty liver disease. The aim of the current study was to explore the effects of picroside II, a phytoactive found in Picrorhiza kurroa, on fatty acid accumulation vis-a-vis silibinin, a known hepatoprotective phytoactive from Silybum marianum. Methods: HepG2 cells were loaded with FFAs (oleic acid:palmitic acid/2:1) for 20 hours to mimic hepatic steatosis. The FFAs concentration achieving maximum fat accumulation and minimal cytotoxicity (500 μM) was standardized. HepG2 cells were exposed to the standardized FFAs concentration with and without picroside II pretreatment. Results: Picroside II pretreatment inhibited FFAs-induced lipid accumulation by attenuating the expression of fatty acid transport protein 5, sterol regulatory element binding protein 1 and stearoyl CoA desaturase. Preatreatment with picroside II was also found to decrease the expression of forkhead box protein O1 and phosphoenolpyruvate carboxykinase. Conclusions: These findings suggest that picroside II effectively attenuated fatty acid accumulation by decreasing FFAs uptake and lipogenesis. Picroside II also decreased the expression of gluconeogenic genes. (Clin Mol Hepatol 2018;24:77-87)
KCI
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
