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( Shiva Pathak ),( Biki Gupta ),( Bijay Kumar Poudel ),( Tuan Hiep Tran ),( Shibha Regmi ),( Tung Thanh Pham ),( Raj Kumar Thapa ),( Min Soo Kim ),( Chul Soon Yong ),( Jong Oh Kim ),( Jee Heon Jeong ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Tacrolimus-loaded poly(lactic-co-glycolic acid) micro spheres (TAC-PLGA-M) can be administered for the long-term survival of transplanted organs due to their immunosuppressive activity. The purpose of our study was to optimize the parameters of the clcctrospray method, and to prepare T AC-PLGA-M with a high payload and desirable release properties. TAC-PLGA-M were prepared using the electrospray method. III vitro characterization and evaluation were performed using scanning electron microscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy. Drug-loading efficiency was greater than 80% in all formulations with a maximum loading capacity of 16.81±0.37%. XRD and DSC studies suggested that the drug was incorporated in an amorphous state or was molecularly dispersed in the microspheres. The ill vitro release study showed prolonged release patterns. TAC-PLGA-M with enhanced drug loading and prolonged-release patterns were successfully prepared using the electro-spray method.