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갑상선 수질암과 갑상선 유두암의 충돌종양: 5예 증례보고
정호철,김제룡,안병현,이진선,장일성,김진만1,Ho Chul Jeong,Je Ryong Kim,Byong Hyon Ahn,Jin Sun Lee,Eil Sung Chang,Jin Man Kim1 대한갑상선-내분비외과학회 2014 The Koreran journal of Endocrine Surgery Vol.14 No.1
Medullary thyroid carcinoma and papillary thyroid carcinoma are different subtypes of thyroid carcinoma. The concomitant occurrence of medullary thyroid carcinoma and papil-lary thyroid carcinoma as a collision tumor is rare. We describe five cases of medullary and papillary thyroid carcinoma as a collision tumor. Four women and one man underwent thyroidectomy for treatment of thyroid cancer. Collision tumor was then detected by histopathologic finding. Genetic testing, point mutation of the BRAF gene or mutation of the RET gene was performed in three cases. However, only one case had point mutation of the BRAF gene. Exact diagnosis of this uncommon event is important because the strategies for treatment of papillary thyroid carcinoma and medullary thyroid carcinoma are different.
Kim, Kyung Hwan,Chi, Zhenguo,Cho, Min Ju,Jin, Jung-Il,Choi, Dong Hoon,Paek, Sang Hyon Wiley - VCH Verlag GmbH & Co. KGaA 2007 Macromolecular Symposia Vol.249 No.-
<P>First generation thiophene-labeled conjugated dendrimers have been synthesized through the Heck coupling reaction between the 5-vinyl-[2,2′]bithio- phenyl derivative and 1,2,4,5-tetrabromo-benzene as a core. One dendrimer has hexyl groups at the periphery and the other does not have it. They display a considerably better solubility than the linear conjugated oligothiophene. We observe drastic spectral change in a film state of dendrimer due to crystallization and a high extent of intermolecular interaction. Effect of peripheral alkyl groups on the intermolecular interaction and lamella orderness was investigated using two dendrimers.</P>
Kim, Sang-Hyon,Chang, Hyuk Won,Choi, Tae Hyun,Kim, Jun Hyung,Son, Daegu,Han, Kihwan,Lee, So Young,Park, Jungbin,Suh, Euy-Hoon,Park, Sung-Hwan Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2010 Annals of plastic surgery Vol.64 No.4
<P>The purpose of this study was to investigate the efficacy of cilostazol for prevention of thrombosis in microsurgical anastomosis. We used not only a patency test, but also ultrasonography to evaluate the blood flow volume (FV) more accurately and objectivity. In addition, we evaluated the accuracy and sensitivity of the patency test. Thrombogenic anastomoses were performed on rat external iliac arteries. Forty-six rats were randomly allocated into the following 5 experimental groups: negative control, without any surgery and medication; control, received distilled water orally; group A, received aspirin orally; group B, received cilostazol orally; and group C, received aspirin and cilostazol orally 3 hours before a thrombogenic artery anastomosis. The artery was evaluated by FV using ultrasonography and a patency test 10, 30, and 120 minutes after clamp removal. The FV in group C was significantly larger than the control group 30 minutes after clamp removal. The FVs in groups A, B, and C were significantly larger than the control group 120 minutes after clamp removal. The FV decreased in all groups with time. The patency rate between the control group and group C 120 minutes after clamp removal was significantly different. There were 8 false negatives in a total of 114 patency tests. The total accuracy and sensitivity of the patency test were 93.0% and 92.7%, respectively. Cilostazol plus aspirin therapy is recommended for reducing thrombosis and increasing FV without increasing the risk of bleeding during microsurgery. The patency test cannot evaluate the state of the anastomotic vessels accurately and objectively.</P>
Serum Pro-hepcidin Could Reflect Disease Activity in Patients with Rheumatoid Arthritis
Kim, Hae-Rim,Kim, Kyoung-Woon,Yoon, So-Young,Kim, Sang-Hyon,Lee, Sang-Heon The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.3
<P>The aim of this study was to analyze the relationship between serum pro-hepcidin concentration and the anemia profiles of rheumatoid arthritis (RA) and to estimate the pro-hepcidin could reflect the disease activity of RA. RA disease activities were measured using Disease Activity Score 28 (DAS28), tender/swollen joint counts, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP). Anemia profiles such as hemoglobin, iron, total iron binding capacity (TIBC), ferritin, and transferrin levels were measured. Serum concentration of pro-hepcidin, the prohormone of hepcidin, was measured using enzyme-linked immunosorbent assay (ELISA). Mean concentration of serum pro-hepcidin was 237.6±67.9 ng/mL in 40 RA patients. The pro-hepcidin concentration was correlated with rheumatoid factor, CRP, ESR, and DAS28. There was a significant correlation between pro-hepcidin with tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. The pro-hepcidin concentration was significantly higher in the patients with active RA (DAS28>5.1) than those with inactive to moderate RA (DAS28≤5.1). However, the pro-hepcidin concentration did not correlate with the anemia profiles except hemoglobin level. There was no difference of pro-hepcidin concentration between the patients with anemia of chronic disease and those without. In conclusion, serum concentration of pro-hepcidin reflects the disease activity, regardless of the anemia states in RA patients, thus it may be another potential marker for disease activity of RA.</P>
Interferon Alpha-2a Reduces Early Erythema After Full-Thickness Skin Graft in the Pig
KIM, JUN SIK,SON, DAEGU,CHOI, TAE HYUN,HAN, KIHWAN,KIM, JUN HYUNG,CHO, HYUN MI,KIM, WON HEE,KIM, SANG-HYON,KIM, NAM GYUN,LEE, KYUNG SUK,HWANG, O. HYUN,ROH, GU SEOB,PARK, JUNGBIN Blackwell Publishing Inc 2009 Dermatologic surgery Vol.35 No.10
<P>BACKGROUND</P><P>Skin grafting is a commonly performed procedure, but studies of changes in the levels of cytokines after skin grafting have not been reported.</P><P>OBJECTIVE</P><P>We examined changes in cytokines and the degree of erythema after skin grafting in pigs in the control group. Interferon alpha (IFN-α) was injected to reduce erythema, and subsequent changes in cytokines and the degree of erythema were examined in the experimental group.</P><P>METHODS</P><P>Vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1), and CD31 were examined using Western blot analysis and immunohistochemistry. The degree of erythema was measured at 2, 4, and 8 weeks using a chromometer.</P><P>RESULTS</P><P>In the control group, VEGF increased at 2 weeks and decreased at 4 and 8 weeks. TSP1 increased over time. CD31 increased to 4 weeks and decreased at 8 weeks. In the experimental group, VEGF was lower at 2 weeks and higher at 8 weeks than in the control group, TSP1 was higher at 2 weeks and lower at 8 weeks, and CD31 was lower at 4 and 8 weeks. Erythema in the experimental group was lower than that in the control group at 2 and 8 weeks.</P><P>CONCLUSION</P><P>IFN-α may be one of the agents that reduces erythema by suppressing excessive revascularization.</P>
Kim, Hyoun-Ah,Lee, Jisoo,Ha, You-Jung,Kim, Sang-Hyon,Lee, Chan-Hee,Choi, Hyo-Jin,Baek, Han-Joo,Lim, Mie Jin,Park, Won,Choi, Sungiae,Hong, Yeon-Sik,Lee, Yoo-Hyun,Koh, Bo-Ram,Suh, Chang-Hee The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.1
<P>Polymyalgia rheumatica is an inflammatory disease affecting elderly and involving the shoulder and pelvic girdles. No epidemiological study of polymyalgia rheumatica was conducted in Korea. We retrospectively evaluated patients with polymyalgia rheumatica followed up at the rheumatology clinics of 10 tertiary hospitals. In total 51 patients, 36 patients (70.6%) were female. Age at disease onset was 67.4 yr. Twenty-three patients (45.1%) developed polymyalgia rheumatica in winter. Shoulder girdle ache was observed in 45 patients (90%) and elevated erythrocyte sedimentation rate (> 40 mm/h) in 49 patients (96.1%). Initial steroid dose was 23.3 mg/d prednisolone equivalent. Time to normal erythrocyte sedimentation rate was 4.1 months. Only 8 patients (15.7%) achieved remission. Among 41 patients followed up, 28 patients (68.3%) had flare at least once. Number of flares was 1.5 ± 1.6. The frequency of flare was significantly lower in patients with remission (<I>P</I> = 0.02). In Korea, polymyalgia rheumatica commonly develops during winter. Initial response to steroid is fairly good, but the prognosis is not benign because remission is rare with frequent relapse requiring long-term steroid treatment.</P>