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RISS 인기검색어
- 검색키워드
- 저자 : ( Madhav Khanal ) (검색결과 2 건)
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( Rojeet Shrestha ),( Madhav Khanal ),( Sunil C Jha ),( Bharat Jha ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hypertension is frequently associated with the development of non-alcoholic liver disease (NAFLD). Although the pathogenesis of NAFLD is poorly understood, there is a considerable amount of evidence that it is associated with abnormal lipid metabolism and dyslipidemia. Therefore, NAFLD not only increases the risk of advanced liver diseases but also associated with future coronary events. Hence, we aimed to examine the association of oxidize-LDL (oxLDL), and high-sensitivity C-reactive protein (hsCRP) in the hypertensive individuals with elevated liver enzymes. Methods: 150 newly diagnosed hypertensive subjects, aged between 30-74 years (male/female:71/79), were recruited. As a control, 150 age- and sex-matched healthy volunteers were also included. Fasting blood samples were analyzed for blood glucose, eGFR, lipid profile, liver function test (bilirubin, ALT, AST, ALP, γ-GT, LDH, albumin, globulin), oxLDL, and hsCRP. Urine samples were analyzed for albumin- creatinine ratio (UACR). Results: Hypertension is significantly associated with elevated serum ALT compared to control. 32.0%, 27.3% and 12.6% of hypertensive individuals have elevated ALT, AST, and γ-GT, respectively. In contrast, only 6.0%, 8.7%, and 2.6% of healthy control have elevated ALT, AST, and γ-GT, respectively. Interestingly, we found significant elevation of oxLDL and hsCRP among the hypertensive individuals with elevated ALT compared to normal ALT level (44.8±24.7 vs 30.65±12.6 U/L, p<0.001 for oxLDL and 4.85±6.6 vs 2.65±3.2 mg/L, p=0.023 for hsCRP). No such association was observed with serum γ-GT. In addition, the level of ALT is significantly correlated with oxLDL in the subjects with elevated ALT (p=0.031). Although the mean of serum triglyceride, total and LDL-cholesterol, UACR, and eGFR is significantly increased in hypertensive subjects compared to controls, no such difference was observed between hypertensive subjects with normal and elevated liver enzymes. Conclusions: Hypertensive subjects with elevated liver enzymes are associated with increase in oxidative and inflammatory markers but not with other traditional cardiac risk factors.
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( Rojeet Shrestha ),( Suraj Parajuli ),( Puja Neopane ),( Madhav Khanal ),( Sunil C Jha ),( Bharat Jha ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The presence of multiple metabolic disorders such as diabetes mellitus, obesity, dyslipidemia, and hypertension is associated with non-alcoholic liver disease (NAFLD) that can potentially progress to severe liver disease. Although the patho genesis of NAFLD is poorly understood, there is a considerable amount of evidence that it is associated with abnormal lipid me tabolism and dyslipidemia. Therefore, NAFLD not only increases the risk of advanced liver diseases but also associated with future coronary events. Hence, we aimed to examine the association Serum lipids, anti-oxidized-LDL Antibody (Anti-oxLDL Ab), and high-sensitivity C-reactive protein (hsCRP) in the metabolic syn drome (MetS) patients with and without elevated liver enzymes. Methods: A total of 82 individuals (male/female:35/47) with MetS as defined by NCEP ATP III, and 68 healthy control (male/ female:36/32), were recruited for this study. Fasting blood samples were analyzed for blood glucose, eGFR, lipid profile, liver function test (bilirubin, ALT, AST, ALP, γ-GT, LDH, albumin, globulin), anti-oxLDL Ab, and hsCRP. Urine samples were ana lyzed for albumin-creatinine ratio (UACR). Results: MetS is significantly associated with elevated serum ALT compared to control. 22.0%, 17.8% and 10.3% of indi viduals with MetS have elevated ALT, AST, and γ-GT, respec tively. In contrast, only 6.0%, 4.7%, and 2.6% of healthy control have elevated ALT, AST, and γ-GT, respectively. Inter estingly, we found significant elevation of anti-oxLDL Ab and hsCRP in MetS with elevated ALT compared to normal ALT level (38.7±24.7 vs 20.35±10.6 U/L, P<0.001 for anti-oxLDL Ab and 5.55±7.6 vs 2.15±1.2 mg/L, P<0.001 for hsCRP). No such as sociation was observed with serum AST and γ-GT. In addition, the level of ALT is significantly correlated with anti-oxLDL Ab and hsCRP in the MetS with elevated ALT (P=0.021). Although the mean of serum triglyceride, total and LDL-cholesterol, UACR, and eGFR is significantly increased in MetS compared to controls, no such difference was observed between MetS with normal and elevated liver enzymes. Conclusions: MetS is associated with elevated liver enzymes. The individuals with MetS with elevated liver enzymes are asso ciated with increase in hsCRP and anti-oxLDL Ab. The oxidative and inflammatory process might involved in progressive deteri oration of liver functions in the MetS.
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