http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
In-Gyu Kim,Byung Seup Kim,Jang Yong Jeon,Jae Woo Kwon,Joo Seop Kim,Doo Jin Kim,Jae Pil Jung,Seong Eun Chon,Han Joon Kim,Eui Yong Jeon,Min-Jeong Kim,Kwanseop Lee 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.3
Liver transplantation with preservation of the recipient vena cava (piggyback technique) has been performed as an alternative to the conventional method. Outflow disturbance or obstruction of the vena cava in the early period after liver transplantation is associated with high morbidity and mortality. We used side-to-side cavo-caval anastomosis (modified piggyback technique) in a deceased-donor liver transplantation (DDLT) for venous outflow reconstruction. On postoperative day 9, the patient developed abdominal discomfort, and abnormal liver function showing serum total bilirubin of 6.2 mg/dl and serum AST/ALT of 297/597 IU/L. Doppler ultrasound showed mono-phasic wave forms of the hepatic vein. Computed tomography showed focal narrowing of 9.5 mm±2 mm in diameter at the cavo-caval anastomosis site. Liver biopsy was showed that there was no evidence of acute allograft rejection. Direct venogram showed stenosis of the cavo-caval anastomosis with a pressure gradient of 12 mmHg. An interventional stent was inserted in the stenotic site of the inferior vena cava, and the pressure gradient decreased to 2 mmHg. He was discharged from hospital on postoperative day 23 without any other complications. Herein we report a case of deceased-donor liver transplantation using the modified piggyback technique, who received an inferior vena cava stent due to stricture of the reconstructed orifice of the vena cava. (Korean J Hepatobiliary Pancreat Surg 2011;15:184-188)
Kim, Kyu-pyo,Park, Seong Joon,Kim, Jeong-Eun,Hong, Yong Sang,Lee, Jae-Lyun,Bae, Kyun-Seop,Cha, Hyunju,Kwon, Sool-Ki,Ro, Seonggu,Cho, JoongMyung,Kim, Tae Won Springer-Verlag 2015 Investigational new drugs Vol.33 No.5
<P>Purpose The aim of the present study was to assess the safety, maximum tolerated dose (MTD), pharmacokinetics, pharmacodynamics, and efficacy of single and multiple doses of intravenous CG200745, a novel histone deacetylase (HDAC) inhibitor, in patients with advanced solid malignancies. Experimental Design Two to six patients received intravenous CG200745 according to the 2?+?4 dose-escalating method. This first-in-human trial was comprised of two parts: Part 1 was a single ascending dose, and Part 2 was multiple ascending doses weekly for 3?weeks, and then 1?week off. For the first cycle, pharmacokinetic sampling for CG200745 and pharmacodynamic sampling for acetylated histone H4 in peripheral blood mononuclear cells (PBMCs) were performed on day 1 for Part 1 and on days 1 and 15 for Part 2. Examination of acetylated histone H4 in pre- and post-biopsy samples was performed in accessible patients. Results In all, 28 patients were treated at 13 dose levels (1.8-250?mg/m(2)) and received a total of 71 cycles of CG200745. Hematologic toxicities included grade 3/4 neutropenia (22.2?%) that did not last a week and non-hematologic toxicities included fatigue (22.2?%) and anorexia (16.7?%) that did not exceed grade 2. No dose-limiting toxic effects were noted. Dose proportionality was observed for both the maximum concentration and area under the curve. The elimination half-life was 5.67??2.69?h (mean??standard deviation). An increase in PBMC acetylated histone H4 was observed at dose levels up to 51?mg/m(2), which plateaued at higher dose levels. At 24?h, 75?% of patients (6/8) showed higher relative acetylation in tumor tissue compared to PBMCs. Although there was no partial or complete response, 57.1?% of patients (16/28) had stable disease that lasted at least 6?weeks. Conclusions CG200745 can be safely administered at effective dose levels that inhibit HDAC in PBMCs and tumor tissue. Although MTD was not reached, further escalation was not performed because acetylated histone H4 plateaued at dose levels higher than 51?mg/m(2). Additional phase II trials are recommended at 250?mg/m(2).</P>
Kim, Yong-Tae,Lee, Seoung-Ki,Kim, Kwang-Seop,Kim, Yong Ho,Ahn, Jong-Hyun,Kwon, Young-Uk American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.15
<P>Graphene displays outstanding properties as an electrode and a semiconducting channel material for transistors; however, the weak interfacial bond between graphene and an inorganic oxide material-based insulator presents a major constraint on these applications. Here, we report a new approach to improving the interface between the two materials using a CdSe quantum dot (QD)-based seeding layer in an inorganic material–graphene junction. CdSe QDs were electrochemically grown on graphene without degrading the properties of the graphene layer. The graphene structure was then used as the electrode in an oxide semiconductor by depositing a zinc oxide thin film onto the graphene coated with a QD seed layer (QD/G). The zinc oxide film adhered strongly to the graphene layer and provided a low contact resistance. A high-k dielectric layer in the form of an HfO<SUB>2</SUB> film, which is an essential element in the fabrication of high-performance graphene-based field effect transistors, was also uniformly formed on the QD/G sheet using atomic layer deposition. The resulting transistors provided a relatively good performance, yielding hole and electron mobilities of 2600 and 2000 cm<SUP>2</SUP>/V·s.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-15/am502922w/production/images/medium/am-2014-02922w_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am502922w'>ACS Electronic Supporting Info</A></P>
Kim, Hee-Seop,Youm, Jin-Young,Kwon, Hyon-Jo,Choi, Seung-Won,Kim, Seon-Hwan,Koh, Hyeon-Song The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.42 No.2
Objective : The authors attempted to evaluate the pattern of the airway narrowing due to prevertebral soft tissue swelling after surgery of the anterior cervical spine and their clinical significances using plain cervical X-ray images. Methods : Twenty-four patients undergoing anterior cervical spine surgery were reviewed from January 2004 to December 2005. Postoperatively, in daily basis, lateral radiograph of the neck was obtained in neutral position. We measured the upper airway diameter above and below the epiglottis level and prevertebral soft tissue diameter every day for a week and finally 2 weeks after surgery using their simple lateral cervical X-ray films. Results : Both airway narrowing and prevertebral soft tissue swelling were maximum in postoperative 2 days, and decreased rapidly in postoperative 7 days. Airway narrowing was aggravated postoperatively but slowly decreased as prevertebral soft tissue swelling diminished. But, the severity of airway narrowing showed no clinical correlations with clinical symptom and radiologic severity. Conclusion : Not all patients who show severe airway narrowing and prevertebral soft tissue swelling on their plain cervical X-ray film complain respiratory insufficiency. But, the patients with undergoing anterior cervical spine surgery should be monitored carefully for respiratory insufficiency, especially during several days following operation because both airway narrowing and prevertebral soft tissue swelling become peak at postoperative 2-3 days.
Kim, Rae-Kwon,Suh, Yongjoon,Yoo, Ki-Chun,Cui, Yan-Hong,Hwang, Eunji,Kim, Hyun-Jin,Kang, Ju-Seop,Kim, Min-Jung,Lee, Young Yiul,Lee, Su-Jae BlackWell Publishing Ltd 2015 CANCER SCIENCE Vol.106 No.1
<P>Metastasis is a challenging clinical problem and the primary cause of death in breast cancer patients. However, there is no therapeutic agent against metastasis of breast cancer cells. Here we report that phloroglucinol, a natural phlorotannin component of brown algae suppresses metastatic ability of breast cancer cells. Treatment with phloroglucinol effectively inhibited mesenchymal phenotypes of basal type breast cancer cells through downregulation of SLUG without causing a cytotoxic effect. Importantly, phloroglucinol decreased SLUG through inhibition of PI3K/AKT and RAS/RAF-1/ERK signaling. In agreement with <I>in vitro</I> data, phloroglucinol was also effective against <I>in vivo</I> metastasis of breast cancer cells, drastically suppressing their metastatic ability to lungs, and extending the survival time of mice. Collectively, our findings demonstrate a novel anticancer activity of phloroglucinol against metastasis of breast cancer cells, implicating its clinical relevance.</P>
Kwon, Mi Jung,Jeon, Jang Yong,Park, Hye-Rim,Nam, Eun Sook,Cho, Seong Jin,Shin, Hyung Sik,Kwon, Ji Hyun,Kim, Joo Seop,Han, Boram,Kim, Dong Hoon,Choi, Yoon-La RAVEN PRESS PUBLISHERS 2015 PANCREAS Vol.44 No.3
OBJECTIVES: Low prevalence and prognostic relevance of KRAS mutations in Korean pancreatic ductal adenocarcinomas (PDACs) need to be validated with sensitive detection method. METHODS: Peptide nucleic acid (PNA)–mediated polymerase chain reaction (PCR) clamping was used to precisely detect KRAS mutation in 72 paraffinized tumor samples and was validated by pancreatic cell lines to compare the efficiency of direct sequencing. RESULTS: The PNA-mediated PCR clamping detected mutant allele proportions of as low as 0.5% against a background of wild-type DNA and was 20-fold more sensitive than direct sequencing through the validation of pancreatic cell lines. Peptide nucleic acid–mediated PCR clamping detected KRAS mutations in 47.2% of 72 PDACs. Low tumor cellularity and low PCR amplification efficiency led to be undetected or failed by direct sequencing in pancreatic paraffinized samples.KRAS mutations were an independent worse prognostic factor predicting a reduced progression-free survival rate in the postoperative chemotherapy group. CONCLUSIONS: Peptide nucleic acid clamp real-time PCR was a sensitive method for detecting KRAS status in paraffinized PDAC samples. We identified a low KRAS mutation rate among the Korean PDAC patients using PNA clamp real-time PCR, potentially implicating epidemiological characteristics. The low KRAS mutation rate and its prognostic role may suggest the further survival benefit in Korean PDAC patients.
Kim, Hoon-Seop,Lee, Dong-Hyun,Seok, Moo-Young,Zhao, Yakai,Kim, Woo-Jin,Kwon, Dongil,Jin, Hyung-Ha,Kwon, Junhyun,Jang, Jae-il Elsevier 2017 Journal of nuclear materials Vol.487 No.-
<P><B>Abstract</B></P> <P>While nanoindentation is a very useful tool to examine the mechanical properties of ion irradiated materials, there are some issues that should be considered in evaluating the properties of irradiated layer. In this study, in order to properly extract the hardness of only-irradiated layer from nanoindentation data, a new procedure is suggested in consideration of the geometry of indentation-induced plastic zone. By applying the procedure to an ion irradiated Fe-12Cr alloy, the reasonable results were obtained, validating its usefulness in the investigation of practical effect of irradiation on the mechanical behavior of future nuclear materials.</P>