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LC, Acute : O-055 ; Protection from liver fibrosis by a PPAR agonist
( Keiko Iwaisako ),( Yong Han Paik ),( Michael Haimer ),( Kojiro Taura ),( Yuzo Kodama ),( Claude Sirlin ),( Elizabeth Yu ),( Ruth T Yu ),( Michael Downes ),( Ronald M Evans ),( David A Brenner ),( Be 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Peroxisome Proliferator-Activated Receptor delta (PPAR), a member of the nuclear receptor family, is emerging as a key metabolic regulator with pleiotropic actions on various tissues including fat, skeletal muscle and liver. The aim of our study was to assess the effect of a new and highly selective PPAR agonist KD3010 in experimental mouse models of liver fibrosis induced by carbon tetrachloride (CCl4) injections or bile duct ligation (BDL). Methods: Male adult C57/B6 mice were treated daily with vehicle or KD3010 by oral gavage. Liver fibrosis was induced by repeated intraperitoneal injections of CCl4 or BDL. For in vitro study, primary hepatocytes were isolated and incubated with/without KD3010. Results: PPAR agonist KD3010 ameliorates liver injury induced by CCl4 injections. Deposition of extracellular matrix proteins was lower in the KD3010 group as compared to the control group. The hepatoprotective and antifibrotic effect of KD3010 was confirmed in a model of cholestasis-induced liver injury and fibrosis using BDL for three weeks. Primary hepatocytes incubated with KD3010 were protected from serum starvation or CCl4-induced cell death, in part due to reduced reactive oxygen species (ROS) production. Conclusions: The PPAR agonist KD3010 has hepatoprotective and antifibrotic effects in animal models of liver fibrosis suggesting a new mechanistic and therapeutic approach in treating patients with chronic liver diseases.
Sclerosing encapsulating peritonitis after living-donor liver transplantation
Vusal Aliyev,Shintaro Yagi,Ahmed Hammad,Amr Badawy,Yudai Sasaki,Yuki Masano,Gen Yamamoto,Naoko Kamo,Kojiro Taura,Hideaki Okajima,Toshimi Kaido,Shinji Uemoto 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.2
Sclerosing encapsulating peritonitis (SEP), or abdominal cocoon is a rare cause of intestinal obstruction, and still etiology remains unknown. We report a series of 4 patients with abdominal cocoon, and all the 4 patients had previously undergone living-donor liver transplantation (LDLT). There was no evidence of SEP before and during LDLT. At the time of diagnosis of SEP, 3 out of 4 patients had ascites. First and fourth patients had multiple episodes or attacks of cholangitis, which were managed by percutaneous transhepatic biliary drainage and hepaticojejunostomy, respectively. All 4 patients presented with intestinal obstruction and 3 of them underwent a successful operation. The fourth patient died due to liver failure and complications of the SEP. The first 3 patients are doing well without SEP recurrence. Our experience suggest that the prognosis of SEP is poor in patients with poor graft liver functions after LDLT.