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- 저자 : ( Karina Khmelnitskaya ) (검색결과 1 건)
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( Karina Khmelnitskaya ),( Eugenii Shlyakhto ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Endothelial Progenitor Cells (EPCs) were fi rst described in 1997 and have since been the subject of numerous investigative studies exploring the potential of these cells in the process of cardiovascular damage and repair. Circulating EPCs are capable of differentiating into mature endothelial cells to assist in angiogenesis and vasculogenesis. Previous studies have suggested an inverse relationship between levels of circulating EPCs and the presence of coronary artery disease (CAD) or cardiovascular risk factors, whereas other studies have observed increased numbers of EPCs in the setting of acute ischemia. We investigated whether the number of EPCs in patients with chronic heart failure (CHF) was associated with severity CAD in patients undergoing coronary angiography, their correlations with the severity of stenosis, cytokines activation, growth factors, other clinic indicators. Methods: Peripheral blood EPCs assessed both as CD133+ cells and CD133+ cells coexpressing CD34 and vascular endothelial growth factor (VEGF) receptor-2 cells were studied in 82 men with ischemic heart disease and CHF I-IV class (NYHA), undergoing coronary angiography. Patients with acute coronary syndroms were excluded. Results: There was an decrease CD133+, CD34+/CD133+/VEGFR2+ cells in men with CHF and 3-vessel CAD, 4-vessel CAD compared 1-vessel CAD (P<0.05). Men with occlusion of coronary artery had lower CD133+, CD34+/CD133+/VEGFR2 cells (P<0.05). CD34+/CD133+/VEGFR2+ cells negative correlated to age, smoking, New York Heart Association class, left ventricular ejection fraction, number of myocardial infarctions, NT-proBNP, and positive - to VEGF, CD34+, CD133+ cells. Conclusions: In patients with CHF there were lower number of EPCs were associated with the presence of signifi cant angiographically CAD and number of vessels CAD, and EPC number correlated with maximum angiographic stenosis severity.
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