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- 저자 : ( Jana Mattova ) (검색결과 1 건)
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( Jana Mattova ),( Pavla Pouckova ),( Petr Urbanek ),( Martin Hruby ),( Jan Kucka ),( Miroslav Vetrik ),( Michaela Skodova ),( Petr Stepanek ),( Milos Petrik ),( Zbynek Novy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Wilson`s disease is a genetic disorder caused by a malfunction of ATPase 7B that leads to high accumulation of copper in the organism and consequent toxic effects. We propose a gentle therapy to eliminate the excessive copper content with oral administration of insoluble non-resorbable polymer sorbents containing selective chelating groups for copper ions (Cu²<sup>+</sup> ions). Methods: Polymeric beads with the chelating agents triethylenetetramine, N,N-di(2-pyridylmethyl)amine and 8-hydroxyquinoline were investigated. We performed a long term experiment with Wistar rats fed a diet containing the particular polymers. Further, we investigated non-resorbability of polymeric beads. We measured organ radioactivity after oral administration of 8-hydroxyquinoline on polymer radiolabelled with iodine-125. Non-resorbability was also tested with small animal PET/CT imaging (using copper-64) in NMR mice. Results: In a long-term experiment with Wistar rats fed a diet containing the polymers, we have found that there were no signs of polymer toxicity and the addition of polymers to the diet led to a significant reduction in the copper contents in the kidneys, brains, and livers of the rats. 8-hydroxyquinoline on polymer radiolabelled with iodine-125 was not absorbed from the digestive tract after oral administration. Non-resorbability was also confirmed with PET/CT imaging. Conclusions: We have shown that polymers containing specific ligands could potentially be novel therapeutics for Wilson`s disease. Polymeric beads significantly reduced copper content in selected organs and they are non-resorbable from digestive tract and fully eliminated in feces after oral administration.
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