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- 저자 : ( Jae We Che ) (검색결과 1 건)
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Maintenance Therapy of Facial Seborrheic Dermatitis with 0.1% Tacrolimus Ointment
( Hye One Kim ),( Yoon Seok Yang ),( Hyun Chang Ko ),( Gyung Moon Kim ),( Sang Hyun Cho ),( Young Joon Seo ),( Sang Wook Son ),( Jong Rok Lee ),( Joong Sun Lee ),( Sung Eun Chang ),( Jae We Che ),( Ch 대한피부과학회 2015 Annals of Dermatology Vol.27 No.5
Background: Topical calcineurin inhibitors (TCIs) have been successfully used to treat seborrheic dermatitis (SD) patients. Meanwhile, treatment of atopic dermatitis (AD) with lowdose, intermittent TCI has been proved to reduce disease flare-ups. This regimen is known as a maintenance treatment. Objective: The aim of this trial was to investigate the efficacy and tolerability of a maintenance treatment with tacrolimus ointment in patients with facial SD. Methods: During the initial stabilization period, patients with facial SD or AD applied 0.1% tacrolimus ointment twice daily for up to 4 weeks. Clinical measurements were evaluated on either in the whole face or on separate facial regions. When an investigator global assessment score 1 was achieved, the patient applied tacrolimus twice weekly for 20 weeks. We also compared our results with recent published data of placebo controlled study to allow an estimation of the placebo effect. Results: The time to the first relapse during phase II was similar in both groups otherwise significantly longer than the placebo group. The recurrence-free curves of two groups were not significantly different from each other; otherwise the curve of the placebo group was significantly different. There were no significant differences between the 2 groups in the number of DEs, and treatment days for disease exacerbations (DEs). The adverse event profile was also similar between the 2 groups. During the 20 weeks of treatment, the study population tolerated tacrolimus ointment well. Conclusion: The results of this study suggest that maintenance treatment with tacrolimus may be effective in preventing the occurrence of facial SD exacerbations. (Ann Dermatol 27(5) 523∼530, 2015)
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