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- 저자 : ( Haak Cheuul Kim ) (검색결과 1 건)
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( Jung Hwan Yu ),( Haak Cheuul Kim ),( In Hee Kim ),( Dae-ghon Kim ),( Gum Mo Jung ),( Yong Keun Cho ),( Eun Young Cho ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Sovaldi plus ribavirin therapy for chronic hepatitis C (CHC) genotype 2 patients are tolerable and highly effective in a shorter period of time than before. However, hematologic complication, especially anemia, can affect the efficacy of these drugs. The aim of this study was to investigate the prevalence of anemia and clinical characteristics of patients with anemia after sovaldi plus ribavirin treatment. Methods: Patients with CHC genotype 2 who underwent sovaldi plus ribavirin therapy at three referral hospitals in Jeollabuk-do Province from May 2016 to February 2017 were enrolled. Results: Total 95 patients (male 49, female 46) underwent sovaldi plus ribavirin therapy. The average age of the patients was 65.4 (30-89). Of 95 patient, 10 (10.5%) reduced ribavirin dose due to significant hemoglobin down. The incidence of anemia was 16.8% (16/95), 21.1% (20/95), 24.2% (23/95) at 4 weeks, 8 weeks, and 12weeks after treatment, respectively. Patients who reduced ribavirin dose showed predominantly low body mass index (BMI), hemoglobin (Hb), hamatocrit (Hct), and platelet at initial lab test. And, the patient with DM showed statistically higher hemoglobin reduction at the end of treatment. Sustained virologic response (SVR) at 12 weeks post-treatment was evaluated in 66 patients. SVR12 was found in 96.9% (64/66) patients. One patient who did not achieve SVR12 had ribavirin dose reduction due to anemia, the other underwent only 12 weeks treatment although he had liver cirrhosis. Conclusions: Most patient who underwent sovaldi plus ribavirin therapy showed higher SVR rate after treatment. However, because of ribavirin side effect, quite a few patients experienced the hemoglobin down and dose reduction. Therefore, we should pay attention to the patient who underwent sovaldi plus rivabirin, especially had lower BMI, Hb, Hct and platelet.
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