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RISS 인기검색어
- 검색키워드
- 저자 : ( Guoxiong Li ) (검색결과 2 건)
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( Jie Li ),( Ping He ),( Xingqi Lu ),( Yun Guo ),( Min Liu ),( Guoxiong Li ),( Jianping Ding ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.2
Background/Aims Depressive symptom is one of the most common symptoms in patients with irritable bowel syndrome (IBS), but its pathogenetic mechanisms remain unclear. As a voxel-level graph theory analysis method, degree centrality (DC) can provide a new perspective for exploring the abnormalities of whole-brain functional network of IBS with depressive symptoms (DEP-IBS). Methods DC, voxel-wise image and clinical symptoms correlation and seed-based functional connectivity (FC) analyses were performed in 28 DEP-IBS patients, 21 IBS without depressive symptoms (nDEP-IBS) patients and 36 matched healthy controls (HC) to reveal the abnormalities of whole brain FC in DEP-IBS. Results Compared to nDEP-IBS patients and HC, DEP-IBS patients showed significant decrease of DC in the left insula and increase of DC in the left precentral gyrus. The DC’s z-scores of the left insula negatively correlated with depression severity in DEP-IBS patients. Compared to nDEP-IBS patients, DEP-IBS patients showed increased left insula-related FC in the left inferior parietal lobule and right inferior occipital gyrus, and decreased left insula-related FC in the left precentral gyrus, right supplementary motor area (SMA), and postcentral gyrus. In DEP-IBS patients, abstracted clusters’ mean FC in the right SMA negatively correlated with depressive symptoms. Conclusions DEP-IBS patients have abnormal FC in brain regions associated with the fronto-limbic and sensorimotor networks, especially insula and SMA, which explains the vicious circle between negative emotion and gastrointestinal symptoms in IBS. Identification of such alterations may facilitate earlier and more accurate diagnosis of depression in IBS, and development of effective treatment strategies. (J Neurogastroenterol Motil 2021;27:248-256)
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Experimental study on water exchange between crack and clay matrix
Song, Lei,Li, Jinhui,Garg, Ankit,Mei, Guoxiong Techno-Press 2018 Geomechanics & engineering Vol.14 No.3
Cracks in soil provide significant preferential pathways for contaminant transport and rainfall infiltration. Water exchange between the soil matrix and crack is crucial to characterize the preferential flow, which is often quantitatively described by a water exchange ratio. The water exchange ratio is defined as the amount of water flowing from the crack into the clay matrix per unit time. Most of the previous studies on the water exchange ratio mainly focused on cracked sandy soils. The water exchange between cracks and clay matrix were rarely studied mainly due to two reasons: (1) Cracks open upon drying and close upon wetting. The deformable cracks lead to a dynamic change in the water exchange ratio. (2) The aperture of desiccation crack in clay is narrow (generally 0.5 mm to 5 mm) which is difficult to model in experiments. This study will investigate the water exchange between a deformable crack and the clay matrix using a newly developed experimental apparatus. An artificial crack with small aperture was first fabricated in clay without disturbing the clay matrix. Water content sensors and suction sensors were instrumented at different places of the cracked clay to monitor the water content and suction changes. Results showed that the water exchange ratio was relatively large at the initial stage and decreased with the increasing water content in clay matrix. The water exchange ratio increased with increasing crack apertures and approached the largest value when the clay was compacted at the water content to the optimal water content. The effective hydraulic conductivity of the crack-clay matrix interface was about one order of magnitude larger than that of saturated soil matrix.
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