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RISS 인기검색어
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- 저자 : ( G. Sarangoo ) (검색결과 1 건)
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( Oidov Baatarkhuu ),( Baasankhuu Enkhtuvshin ),( G. Sarangoo ),( S. Tsogtsaikhan ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Hepatitis C is one of actual health problem of the country. So we have rised the aim to establish peculirity of cell immunity and immunogenetics of patients with hepatitis C and to search ways for elimination of virus and immunocorrection. Methods: There were enrolled total 85 patients (47 males and 38 females) and 64 of them were with chronic and 21 patients with acute hepatitis C. Count of CD3+,CD4+,CD8+ cells (cell/mm3) and CD4/CD8 ratio in 64 patients with chronic hepatitis C were determined by flowcytometry using “BD-FACS count” machine. Lymphocyte blasttransformation reaction with T cell mytogen-phetohemoagglutinin (PHA) were performed in 25 patients with chronic hepatitis C and 15 healthy individuals (rational design sertificate No 1798 from Intellectual Property Autority of Mongolia). For purpose of elimination of virus and immunocorrection aIFN 2b and ribavirin therapy were used in 52 patients with hepatitis C and calculated portion of patients with sustainable viral response (SVR). Results: Count of lymphocytes (BТL2-BТL1) went under blasttransformation by stimulation of PHA was lower (p<0.05) in patients with chronic HC compared to control individuals. There were no side factors excluding PHA (placebo: BТL1=26.11; BТL2=26.00; BТ L2-BTL1=-0.11). It was found lower blastransformation activity (BТL2-BТL1) in patients with CD4+ cell count less than 800 cell/мм3 compared to patients with CD4+ cell count more than 800 cell/мм3 (p<0.05). Number of blasttransformed T cells had direct correlation with count of CD4+T cells (r=0.424) but had indirect correlation with count of CD8+T cells (r= - 0.77). There were more clear manifestation of clilnical signs and elevated serum ALAT level in patients with decreased CD4/CD8 ratio compared to patients with normal ratio. Decrease of CD4/CD8 ratio were caused by increased count of CD8 T cells (CD8 count: 1030±117.3 in patients with clear clinical manifestation and 573.4±98.3 in patients with inclear clinical manifestation, t=3.45, p<0.01). 71.4% of 21 patients (15 males, 6 females, aged 19-44, mean age 27.2±3.4) with acute HC developed SVR after 6 month single IFN therapy. 12 month combined IFN and ribavirin therapy were used in 31 patient patients (15 males, 16 females, mean age 45.4±4.5) with chronic HC. 45.1% of them developed SVR, 42% - PR and 12.9% had not demonstrate no response-NR. Conclusions: There were found disregulation of cell immune response in chronic HCV patients which demonstrated with decreased CD4 count and CD4/CD8 ratio, increased CD8 count and decreaed blasttransformation activity of T cells. Increased CD8+Т cell count was correlated with clear clinical manifestation, low blasttransformation activity of peripheral T cells and elevated level of serum ALAT. Interferon therapy is effective in patients with HC infection for elimi nation of virus and immunocorrection. Sustainable virus response was observed in 71.4% of patients with acute HC and in 45.1% of patients with chronic hepatitis C.
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