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        Degrees of Freedom of Multi-Cell MIMO Interference Broadcast Channels With Distributed Base Stations

        ( Hongbing Huang ),( Junyi Liu ),( Yi Zhang ),( Qing Cai ),( Bowei Zhang ),( Fengwen Jiang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.2

        In this paper, we investigate the degrees of freedom (DoF) of a multi-cell multi-user multiple-input multiple-output (MIMO) interference broadcast channel (IBC) with non-cooperation distributed base stations (BS), where each BS serves users of its corresponding cell. When all BSs simultaneously transmit their own signals over the same frequency band in the MIMO IBC, the edge users in each cell will suffer the inter-cell interference (ICI) and inter-user interference (IUI) signals. In order to eliminate the ICI and IUI signals, a distributed space time interference alignment (DSTIA) approach is proposed where each BS has only limited access to distributed moderately-delay channel state information at the transmitter (CSIT). It is shown that the DSTIA scheme can obtain the appreciate DoF gains. In addition, the DoF upper bound is asymptotically achievable as the number of antenna at each BS increases. It is shown that the DSTIA method can get DoF gains over other interference alignment schemes with delayed CSIT in literature. Moreover, the DSTIA method can attain higher DoFs than the IA schemes with global CSIT for certain antenna configurations.

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        A novel M2e-multiple antigenic peptide providing heterologous protection in mice

        Feng Wen,Ji-Hong Ma,Hai Yu,Fu-Ru Yang,Meng Huang,Yan-Jun Zhou,Ze-Jun Li,Xiu-Hui Wang,Guo-Xin Li,Yi-Feng Jiang,Wu Tong,Guangzhi Tong 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.1

        Swine influenza viruses (SwIVs) cause considerable morbidity and mortality in domestic pigs, resulting in a significant economic burden. Moreover, pigs have been considered to be a possible mixing vessel in which novel strains loom. Here, we developed and evaluated a novel M2e-multiple antigenic peptide (M2e-MAP) as a supplemental antigen for inactivated H3N2 vaccine to provide cross-protection against two main subtypes of SwIVs, H1N1 and H3N2. The novel tetra-branched MAP was constructed by fusing four copies of M2e to one copy of foreign T helper cell epitopes. A high-yield reassortant H3N2 virus was generated by plasmid based reverse genetics. The efficacy of the novel H3N2 inactivated vaccines with or without M2e-MAP supplementation was evaluated in a mouse model. M2e-MAP conjugated vaccine induced strong antibody responses in mice. Complete protection against the heterologous swine H1N1 virus was observed in mice vaccinated with M2e-MAP combined vaccine. Moreover, this novel peptide confers protection against lethal challenge of A/Puerto Rico/8/34 (H1N1). Taken together, our results suggest the combined immunization of reassortant inactivated H3N2 vaccine and the novel M2e-MAP provided cross-protection against swine and human viruses and may serve as a promising approach for influenza vaccine development.

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