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RISS 인기검색어
- 검색키워드
- 저자 : ( Faruk Aksoy ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats
Fadlullah Aksoy,Remzi Dogan,Orhan Ozturan,Selahattin Tugrul,Bayram Veyseller,Omer Faruk Ozer,Alev Pektas 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.4
Objectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.
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Ischemic Necrosis of the Cecum; A Single Center Experience
( Ebubekir Gundes ),( Tevfik Kucukkartallar ),( Muzaffer Haldun ?olak ),( Murat Cakir ),( Faruk Aksoy ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.5
Background/Aims: Isolated cecal necrosis is a rare cause of the surgical abdomen. Its manifestation is similar to that of acute appendicitis. Thirteen cases, who were pre-diagnosed with acute abdomen and were finally diagnosed with isolated cecal necrosis after operation have been evaluated alongside with literature. Methods: The records of 13 patients, who had isolated cecal necroses between 1995 and 2011 at Necmettin Erbakan University Meram Medical School`s General Surgery Clinic (Turkey), were retrospectively evaluated. Results: Eight of the patients were male, whereas 5 were female. Their mean age was 68.0±11.7 (range 51-84) years. All the patients had at least one accompanying disease the most frequent of which were heart failure and chronic renal failure. Ten patients had right hemicolectomy and ileotransversostomy, two had right hemicolectomy and ileostomy, and one had wedge resection to the cecum by the help of linear stapler. Mortality was seen in 5 patients (38%) in the early postoperative period. Conclusions: Isolated cecal necrosis should be considered in elderly patients with chronic diseases presenting with sudden right lower quadrant pains in the differential diagnosis. Isolated cecal necrosis may have a bad prognosis since it is seen in elderly patients with accompanying problems. Therefore, early diagnosis and immediate surgical management if necessary is important to reduce the risk of morbidity and mortality.
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