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( Yong Jun Choi ),( Eun Bee Kwak ),( Jae Won Lee ),( Yong Suk Lee ),( Il Young Cheong ),( Hee Jae Lee ),( Sung Soo Kim ),( Myong Jo Kim ),( Yong Soo Kwon ),( Wan Joo Chun ) 한국응용약물학회 2011 Biomolecules & Therapeutics(구 응용약물학회지) Vol.19 No.2
Neuronal cell death is a common characteristic feature of a variety of neurodegenerative disorders including Alzheimer`s disease and Parkinson`s disease. However, there have been no effective drugs to successfully prevent neuronal death in those diseases. In the present study, docosyl cafferate (DC), a derivative of caffeic acid, was isolated from Rhus verniciflua and its protective effects on tBHP-induced neuronal cell death were examined in SH-SY5Y human neuroblastoma cells. Pretreatment of DC signify cantly attenuated tBHP-induced neuronal cell death in a concentration-dependent manner. DC also significantly suppressed tBHP-induced caspase-3 activation. In addition, DC restored tBHP-induced depletion of intracellular Bcl-2, an anti-apoptotic member of the Bcl-2 family. Furthermore, DC signifi cantly suppressed tBHP-induced degradation of IKB, which retains NF-kB in the cytoplasm, resulting in the suppression of nuclear translocation of NF-kB and its subsequent activation. Taken together, the results clearly demonstrate that DC exerts its neuroprotective activity against tBHP-induced oxidative stress through the suppression of nuclear translocation of NF-kB.
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Evaluation of concurrent immunizations with equine influenza virus and strangles vaccines
( Dong-ha Lee ),( Kyungmin Jang ),( Taemook Park ),( Youngjong Kim ),( Kyoung Hwan Kim ),( Eun-bee Lee ),( Young Beom Kwak ),( Eun-ju Ko ) 한국동물위생학회 2023 韓國家畜衛生學會誌 Vol.46 No.4
Despite regular vaccinations, equine influenza virus (EIV) and Streptococcus equi subsp. equi (strangles) are the cause of highly contagious respiratory infections in horses. Many recent studies have reported that the concurrent administration of two vaccines could simplify horse management and minimize veterinary expenses. However, there is little information available regarding the efficacy of concurrent vaccinations against EIV and strangles. In this study, we evaluated EIV-specific antibody responses following the single EIV vaccination with the recombinant viral-vectored EIV vaccine or concurrent vaccination with the EIV and inactivated strangles vaccines. Blood samples were collected at 1-, 2-, 4-, and 8 weeks post-immunization (wpi) from each group. EIV-specific antibodies were evaluated by enzyme-linked immunosorbent assay (ELISA) and hemagglutination inhibition (HAI) assay. Both single and concurrent vaccination showed similar levels of EIV-specific serum immunoglobulin g (IgG) at 1 and 2 wpi. However, at 4 to 8 wpi, the EIV-only vaccination group showed significantly higher serum IgG levels than those from the concurrently vaccinated group. The HAI titers showed similar trends as the ELISA data, except at 8 wpi when both groups presented HAI titers with no significant differences. These data demonstrate that the concurrent vaccination against EIV and strangles could compromise the humoral immune response to equine influenza between vaccination intervals, which suggests the use of the consecutive vaccination protocol for EIV and strangles rather than concurrent vaccination.
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