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( Amaylia Oehadian ),( Emmy Pranggono ),( Uun Sumardi ),( Hadi Jusuf ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Monocytes could be infected with infi uenza virus and induce rapid differentiation into myeloid dendritic cells (mDCs). Virus-induced mDCs secreted chemoattractants for monocytes (MCP-1 and IP-10). We aim to evaluate monocyte, chemoattractans for monocytes and IFNalpha in infi uenza virus H5N1 and H1 N1. Secondary data were evaluated from medical record of H5N1(n=10) and H1N1 ( n=8) who were hospitalized in Hasan Sadikin Hospital since 2005. MCP-1, IP-10 and IFNalpha were evaluated using secondary data from previous study by Jusuf H : A Comparison of cytokine level between infi uenza A (H5N1) with infi uenza A (pH1N1) Mann Whitney test was used for comparison between H5N1 and H1N1, survive and death subjects. The correlation between chemoattractans for monocytes (MCP-1 and IP-10), IFNalpha and monocyte count were calculated using Spearmann correlation test. Monocyte count was lower in H5N1 compare to H1N1 (90 (0-240) vs 139 (36-560)/mm3, p 0. 17). Monocyte count was higher in survive compare to death subjects (150 (0-560) vs 75 (36-240) /mm3, p 0. 09). The death subjects had signifi cantly higher MCP-1, IP10 and IFNaplha (2171. 5 (985- 10000) vs 674. 4 (450. 2-1209. 3) pg/ml, p 0. 03, 3186. 9 (2436, 2-3937. 6) vs 971. 4 (520, 7-2387. 4) pg/ml, p 0. 03 and 354. 0 (87-2499. 8) vs 18, 6 (1. 41-184) pg/ml, p 0. 003, respectively). There was strong and signifi cant negative correlation between monocytes count and MCP-1 ( R -0. 8, p 0. 042) and between monocytes count andIP-10 ( R -0. 8, p 0. 019). Monocyte count could be used to characterized the severity of infi uenza viral infection. The lower monocyte count correlate with the higher chemoattractant for monocytes produced by mDCs.
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