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- 저자 : ( Cc Szeto ) (검색결과 1 건)
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( Pyk Poon ),( Bch Kwan ),( Hy Lan ),( Xr Huang ),( Cc Szeto ),( Pkt Lii ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: C-reactive protein (CRP) is a mediator of systemic infi ammation. Peritoneal dialysis (PD) is known to cause peritoneal infi ammation and fi brosis. We study the degree of peritoneal infi ammation and fi brosis in CRP-transgenic (Tg) mice before and after PD treatment. Methods: Wild-type (WT) and CRP-Tg C57 mice (all male, 10-12 weeks old) were injected intra-peritoneally with 4.25% dextrose PD solution (3ml/mouse) daily for 28 days, followed by a 4-hour peritoneal equilibration test (PET). The mice were then sacrifi ced. Parietal peritoneum and omental tissues were collected for the assessment of infi ammation and fi brosis. Results: After 28 days of PD, CRP-Tg mice had higher dialysate creatinine and dialysate- to-plasma (D/P) creatinine ratio than WT mice. Parietal peritoneum of the CRP-Tg mice was more cellular than that of the WT mice. CRP-Tg mice also had higher connective tissue growth factor (CTGF), intercellular adhesion molecule 1 (ICAM1) and tumor necrosis factor a (TNFa) RNA expressions as well as immunohistochemical staining in the parietal peritoneum than the WT mice. In addition, CRP-Tg mice had significantly more a-smooth muscle actin (aSMA) in the parietal peritoneum and omentum than WT mice. Conclusions: CRP-Tg mice have signifi cantly more infi ammation and fi brosis than WT mice after PD treatment. Our results suggest that CRP is an important mediator of the infi ammation and fi brosis induced by PD. The implication of our results to human PD therapy needs further investigation.
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