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( Arzu Olgun ),( Ergül Türkmen ) 호남수학회 2020 호남수학학술지 Vol.42 No.3
A module M is called ss-semilocal if every submodule U of M has a weak supplement V in M such that U∩V is semisimple. In this paper, we provide the basic properties of ss-semilocal modules. In particular, it is proved that, for a ring R, RR is ss- semilocal if and only if every left R-module is ss-semilocal if and only if R is semilocal and Rad(R) ⊆ Soc(RR). We define projective ss-covers and prove the rings with the property that every (simple) module has a projective ss-cover are ss-semilocal.
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Prognostic Value of SPARC Expression in Unresectable NSCLC Treated with Concurrent Chemoradiotherapy
Kurtul, Neslihan,Eroglu, Celalettin,Unal, Dilek,Tasdemir, Erdem Arzu,Orhan, Okan,Zararsiz, Gokmen,Baran, Munevver,Kaplan, Bunyamin,Kontas, Olgun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Background: The aim of the present study was to determine the predictive/prognostic value of the secreted protein, acidic and rich in cysteine (SPARC) in cases of unresectable, locally advanced, non-small cell lung cancer. Materials and Methods: The study included 84 patients with Stage IIIA-B non-small cell lung cancer, undergoing simultaneous chemoradiotherapy including radiotherapy at a dose of 66 Gy and weekly docataxel ($20mg/m^2$) and cisplatin ($20mg/m^2$). SPARC expression was studied in biopsy material by immunohistochemical methods and correlations with treatment responses or survival were evaluated. Results: Median overall survival was $16{\pm}2.73$ (11.55-20.46) months for low expression vs $7{\pm}1.79$ months (7.92-16.08) months for high expression (p=0.039), while median local control was $13{\pm}2.31$ (8.48-17.5) months for low expression vs $6{\pm}0.85$ (4.34-7.66) months for high expression (p=0.045) and median progression-free survival was $10{\pm}2.31$ (5.48-14.5) months for low expression vs $6{\pm}1.10$ (3.85-8.15) months for high expression (p=0.022). In both univariate and multivariate analyses, high SPARC expression was associated with significantly shorter overall survival (p=0.003, p=0.007, respectively), local control (p=0.008, p=0.036) and progression-free survival (p=0.004, p=0.029) when compared to low SPARC expression. No significant difference was detected between high and low SPARC expression groups regarding age, sex, T stage, N stage, histopathology and stage-related patient characteristics. Conclusions: High SPARC expression was identified as a poor prognostic factor in cases with locally advanced NSCLC treated with concurrent chemoradiotherapy.
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