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RISS 인기검색어
- 검색키워드
- 저자 : ( Aminat Karimova ) (검색결과 2 건)
- 무료
- 기관 내 무료
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( Suleyman Mamimaev ),( Aminat Karimova ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The adipocytokine/hormone leptin produced by adipose tissue plays the key role in pathogenesis of metabolic syndrome (MS) and its main components: insulin resistance (IR), arterial hypertension and dyslipidemia. Objectives: to reveal the correlations between the leptin level and the most important MS components parameters. Methods: 115 persons included in the study were divided into two groups: the main group - 90 patients (36 men and 54 women) with MS, mean age 50,6±7,3 years, and the control group - 25 healthy people (11 men and 14 women), mean age - 37,1±7,2 years. The anthropometrical measurements, biochemical blood analyses, heart and liver ultrasonography and fasting serum insulin and leptin levels estimation (by ELISA) were carried out in both groups. IR index was evaluated by Homeostasis Model Assessment 2 (HOMA2) calculator (version 2.2.). Results: The mean leptin level in patient with MS was 56,9±27,5 that was signifi cantly higher than in control group (p<0,001). Reliable positive correlations between the BMI, the waist circumference (WC) and leptin level, and negative correlation of a hormone rate with waist-to-hip ratio (WHR) were revealed in the study (R (Spirmen correlation coeffi cient) = 0,36, p<0,001; R=0,29, p=0,006 and R = - 0,6, p<0,001 for BMI, WC and WHR, respectively). Reliable positive correlations between leptin level and systolic and diastolic BP were also revealed (R=0,5, p<0,001 and R=0,34, p=0,001 for SBP and DBP, respectively). More over, leptin level showed strong reliable positive correlation with fasting serum insulin level, IR-NOMA2 and cholesterol level (R=0,59, p<0,001; R=0,65, p<0,001; R=0,23, p=0,04 for insulin, IR-NOMA2 and cholesterol, respectively,). Conclusions: There was revealed the raised serum leptin level in patients with MS compared to healthy people. Leptin level signifi cantly correlated with the parameters that characterize the most important components of MS.
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( Suleyman Mammaev ),( Aminat Karimova ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The central obesity and arterial hypertension (AH) are associated with the basic pathogenetic mechanism of metabolic syndrome (MS) - insulin resistance (IR). Leptin - the adipose tissue hormone/cytokine plays an important role in AH pathogenesis in MS. Objectives: to find out the influence of antihypertensive therapy in MS patients with AH on the leptin level. Methods: 65 persons included in the study were divided into two groups: the main group - 40 patients (15 men and 25 women) with AH and MS, mean age 49,0±6,2 years, and the control group - 25 healthy people (11 men and 14 women), mean age - 43,7±7,2 years. The main group was randomized into two subgroups: 20 patients of the first subgroup were treated by lisinopril (5-10 mg per day) and 20 patients of the second subgroup - by bisoprolol (5-10 mg per day) during 12 weeks. The anthropometrical measurements, biochemical blood analyses, fasting serum insulin and leptin levels estimations (by ELISA) were carried out in both groups before and after the therapy. IR index was evaluated by Homeostasis Model Assessment 2 (HOMA2) calculator. Results: The mean baseline leptin levels were reliably higher in both subgroups compared to control group (56,1±35,3 ng/ml and 58,2±25,5 ng/ml, p<0,001). The decrease of its levels was revealed in both groups, but just in lisinopril subgroup these changes were statistically reliable (Δ= -6,67±6,8 ng/ml, p<0,001 and Δ= 1,47±5,94 ng/ml, p>0,05). IR-HOMA2 that was significantly increased in both subgroups at baseline also reliably decreased only in the first subgroup (Δ IR-HOMA2 = -0,73±1,25, p=0,02). Conclusions: The antihypertensive therapy with lisinopril leads to IR-HOMA2 and serum leptin levels decrease that can demonstrate the pathogenetic effects of lisinopril in MS, while bisoprolol doesn`t influence significantly those parameters.
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