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Beetroot 섭취가 경계성 고혈압자의 GroupIV 대사적 수용기에 미치는 영향
김보희(Bo Hee Kim),최현민(Hyun Min Choi),노호성(Hosung Nho),김경애(Kyung Ae Kim),정은지(Eun Ji Jung),김종경(Jong Kyung Kim) 한국발육발달학회 2014 한국발육발달학회지 Vol.22 No.3
It is reported that beetroot juice supplementation reduces blood pressure in healthy subjects at rest. However, It is not known that beetroot juice supplementation alters the pressor response mediated during exercise and by the muscle metaboreflex activation in prehypertension. Thus, the purpose of this study was to investigate the effects of dietary nitrate derived from beetroot (BR) on muscle metaboreflex and endothelial function in prehypertension compared with placebo (PR). Eleven prehypertensives (24±2 yrs) were recruited in this study. All subjects were assigned in a randomized, double-blind, crossover design to receive BR (70 mL/ day, ~5.6 mmol of NO3 -and PL (70 mL/day, no NO3 -) for 15 days. The subjects completed 2 min static handgrip exercise at 50% maximal voluntary contraction followed immediately by post exercise muscle ischemia(PEMI). On day 15, the same protocol was repeated after BR or PL supplementation. All subjects were continuously instrumented to measure heart rate, stroke volume, systolic blood pressure (SBP), diastolic blood pressure (DBP), and obtain cardiac output(CO), mean arterial pressure(MAP), total peripheral resistance (TPR) at rest and during static exercise and PEMI. Compared with PL, BR significantly increased resting plasma nitrate/nitrite (NOx) concentration (PL: 147.8±10.3 vs. BR: 193.7±19.2, p <.05) and decreased SBP (133±1 vs 128±2 mmHg, p <.05). Normalized flow mediated dilation (FMD) was significantly increased (BR: 2.24±0.3 vs PL: 1.86±0.2, p <.05). There were no differences in CO, MAP, and TPR between BR and PL at rest and during static exercise and muscle metaboreflex activation. Thus, this study indicates that beetroot juice supplementation improves the endothelium function and reduce blood pressure at rest, while no effects on muscle metaboreflex. Therefore, this study suggests that BR diet are regarded as healthy and associated with low incidence of cardiovascular disease in prehypertention.
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