Beetroot 섭취가 경계성 고혈압자의 GroupIV 대사적 수용기에 미치는 영향 = Effect of Beetroot Juice on Muscle Metaboreflex and Endothelial Function in Prehypertention

다국어 초록 (Multilingual Abstract)

It is reported that beetroot juice supplementation reduces blood pressure in healthy subjects at rest. However, It is not known that beetroot juice supplementation alters the pressor response mediated during exercise and by the muscle metaboreflex activation in prehypertension. Thus, the purpose of this study was to investigate the effects of dietary nitrate derived from beetroot (BR) on muscle metaboreflex and endothelial function in prehypertension compared with placebo (PR). Eleven prehypertensives (24±2 yrs) were recruited in this study. All subjects were assigned in a randomized, double-blind, crossover design to receive BR (70 mL/ day, ~5.6 mmol of NO3 -and PL (70 mL/day, no NO3 -) for 15 days. The subjects completed 2 min static handgrip exercise at 50% maximal voluntary contraction followed immediately by post exercise muscle ischemia(PEMI). On day 15, the same protocol was repeated after BR or PL supplementation. All subjects were continuously instrumented to measure heart rate, stroke volume, systolic blood pressure (SBP), diastolic blood pressure (DBP), and obtain cardiac output(CO), mean arterial pressure(MAP), total peripheral resistance (TPR) at rest and during static exercise and PEMI. Compared with PL, BR significantly increased resting plasma nitrate/nitrite (NOx) concentration (PL: 147.8±10.3 vs. BR: 193.7±19.2, p <.05) and decreased SBP (133±1 vs 128±2 mmHg, p <.05). Normalized flow mediated dilation (FMD) was significantly increased (BR: 2.24±0.3 vs PL: 1.86±0.2, p <.05). There were no differences in CO, MAP, and TPR between BR and PL at rest and during static exercise and muscle metaboreflex activation. Thus, this study indicates that beetroot juice supplementation improves the endothelium function and reduce blood pressure at rest, while no effects on muscle metaboreflex. Therefore, this study suggests that BR diet are regarded as healthy and associated with low incidence of cardiovascular disease in prehypertention.

참고문헌 (Reference)

1 이운재, "유산소운동에 따른 대사적 수용기 자극시 운동승압반사의 변화" 한국발육발달학회 19 (19): 185-189, 2011

2 통계청, "사망원인통계자료"

3 최현민, "비만 중년여성들의 운동강도에 따른 심혈관 반응에 관한 연구" 한국발육발달학회 18 (18): 187-194, 2010

4 Stuehr, D. J., "Update on mechanism and catalytic regulation in the NO synthases" 279 (279): 36167-36170, 2004

5 Lundberg, J. O., "The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics" 7 (7): 156-167, 2008

6 Bailey, S. J., "The nitrate-nitrite-nitric oxide pathway : Its role in human exercise physiology" 12 (12): 309-320, 2012

7 Chobanian, A. V., "Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure" 42 (42): 1206-1252, 2003

8 Gladwin, M. T., "Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans" 97 (97): 11482-11487, 2000

9 Mainous, A. G. 3rd., "Prehypertension and mortality in a nationally representative cohort" 94 (94): 1496-1500, 2004

10 Kleinbongard, P., "Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals" 35 (35): 790-796, 2003

11 Kleinbongard, P., "Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans" 40 (40): 295-302, 2006

12 Kapil, V., "Physiological role for nitratereducing oral bacteria in blood pressure control" 55 : 93-100, 2013

13 Curtis, E., "Oxygen regulates tissue nitrite metabolism" 17 (17): 951-961, 2012

14 DiCarlo, S. E., "Onset of exercise shifts operating point of arterial baroreflex to higher pressures" 262 (262): H303-H307, 1992

15 Cosby, K., "Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation" 9 (9): 1498-1505, 2003

16 Kapil, V., "Inorganic nitrate supplementation lowers blood pressure in humans: Role for nitrite-derived NO" 56 (56): 274-281, 2010

17 Bailey, S. J., "Influence of repeated sprint training on pulmonary O2 uptake and muscle deoxygenation kinetics in humans" 106 (106): 1875-1887, 2009

18 Julius, S., "Feasibility of treating prehypertension with an angiotensin-receptor blocker" 354 (354): 1685-1697, 2006

19 Eldridge, F. L., "Exercise hyperpnea and locomotion: Parallel activation from the hypothalamus" 211 (211): 844-846, 1981

20 Zweier, J. L., "Enzyme-independent formation of nitric oxide in biological tissues" 1 (1): 804-809, 1995

21 Landmesser, U., "Endothelial function and hypertension" 22 (22): 316-320, 2007

22 Larsen, F. J., "Effects of dietary nitrate on oxygen cost during exercise" 191 (191): 59-66, 2007

23 Larsen, F. J., "Effects of dietary nitrate on blood pressure in healthy volunteers" 355 (355): 2792-2793, 2006

24 Kaufman, M. P., "Effect of ischemia on responses of group III and IV afferents to contraction" 57 (57): 644-650, 1984

25 Stokes, K. Y., "Dietary nitrite prevents hypercholesterolemic microvascular inflammation and reverses endothelial dysfunction" 296 (296): H1281-H1288, 2009

26 Shiva, S., "Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration" 100 (100): 654-661, 2007

27 Huang, A., "Contrasting effects of thiol-modulating agents on endothelial NO bioactivity" 281 (281): C719-C725, 2001

28 Drukteinis, J. S., "Cardiac and systemic hemodynamic characteristics of hypertension and prehypertension in adolescents and young adults: The strong heart study" 115 (115): 221-227, 2007

29 Webb, A. J., "Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite" 51 (51): 784-790, 2008

30 Vanhatalo, A., "Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderateintensity and incremental exercise" 299 (299): R1121-R1131, 2010

31 성윤희, "12주간 유산소 운동이 비만 중년여성의 총콜레스테롤, 혈압, 뇌혈류 속도에 미치는 영향" 한국발육발달학회 20 (20): 27-34, 2012