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RISS 인기검색어
- 검색키워드
- 주제어 : apicoplast (검색결과 3 건)
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Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives
Mukherjee, Avinaba,Sadhukhan, Gobinda Chandra KOREAN PHARMACOPUNCTURE INSTITUTE 2016 Journal of pharmacopuncture Vol.19 No.1
Objectives: Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials drug which is more target specific. Malarial parasites harbor a plastid-like organelle known as the 'apicoplast', which is thought to provide an exciting new outlook for the development of drugs to be used against the parasite. This review elaborates on the current state of development of novel compounds targeted againstemerging malaria parasites. Methods: The apicoplast, originates by an endosymbiotic process, contains a range of metabolic pathways and housekeeping processes that differ from the host body and thereby presents ideal strategies for anti-malarial drug therapy. Drugs are designed by targeting the unique mechanism of the apicoplasts genetic machinery. Several anabolic and catabolic processes, like fatty acid, isopenetyl diphosphate and heme synthess in this organelle, have also been targeted by drugs. Results: Apicoplasts offer exciting opportunities for the development of malarial treatment specific drugs have been found to act by disrupting this organelle's function, which wouldimpede the survival of the parasite. Conclusion: Recent advanced drugs, their modes of action, and their advantages in the treatment of malaria by using apicoplasts as a target are discussed in this review which thought to be very useful in desigining anti-malarial drugs. Targetting the genetic machinery of apicoplast shows a great advantange regarding anti-malarial drug design. Critical knowledge of these new drugs would give a healthier understanding for deciphering the mechanism of action of anti-malarial drugs when targeting apicoplasts to overcome drug resistance.
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Anti-malarial Drug Design by Targeting Apicoplasts: New Perspectives
Avinaba Mukherjee,Gobinda Chandra Sadhukhan 대한약침학회 2016 Journal of pharmacopuncture Vol.19 No.1
Objectives: Malaria has been a major global health problem in recent times with increasing mortality. Current treatment methods include parasiticidal drugs and vaccinations. However, resistance among malarial parasites to the existing drugs has emerged as a significant area of concern in anti-malarial drug design. Researchers are now desperately looking for new targets to develop anti-malarials drug which is more target specific. Malarial parasites harbor a plastid-like organelle known as the ‘apicoplast’, which is thought to provide an exciting new outlook for the development of drugs to be used against the parasite. This review elaborates on the current state of development of novel compounds targeted againstemerging malaria parasites. Methods: The apicoplast, originates by an endosymbiotic process, contains a range of metabolic pathways and housekeeping processes that differ from the host body and thereby presents ideal strategies for anti-malarial drug therapy. Drugs are designed by targeting the unique mechanism of the apicoplasts genetic machinery. Several anabolic and catabolic processes, like fatty acid, isopenetyl diphosphate and heme synthess in this organelle, have also been targeted by drugs. Results: Apicoplasts offer exciting opportunities for the development of malarial treatment specific drugs have been found to act by disrupting this organelle’s function, which wouldimpede the survival of the parasite. Conclusion: Recent advanced drugs, their modes of action, and their advantages in the treatment of malaria by using apicoplasts as a target are discussed in this review which thought to be very useful in desigining anti-malarial drugs. Targetting the genetic machinery of apicoplast shows a great advantange regarding anti- malarial drug design. Critical knowledge of these new drugs would give a healthier understanding for deciphering the mechanism of action of anti-malarial drugs when targeting apicoplasts to overcome drug resistance.
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Plasmodium falciparum apicoplast and its transcriptional regulation through calcium signaling
Praveen Rai,Drista Sharma,Rani Soni,Nazia Khatoon,Bhaskar Sharma,Tarun Kumar Bhatt 한국미생물학회 2017 The journal of microbiology Vol.55 No.4
Malaria has been present since ancient time and remains amajor global health problem in developing countries. Plasmodiumfalciparum belongs to the phylum Apicomplexan,largely contain disease-causing parasites and characterizedby the presence of apicoplast. It is a very essential organelleof P. falciparum responsible for the synthesis of key moleculesrequired for the growth of the parasite. Indispensablenature of apicoplast makes it a potential drug target. Calciumsignaling is important in the establishment of malaria parasiteinside the host. It has been involved in invasion and egressof merozoites during the asexual life cycle of the parasite. Calcium signaling also regulates apicoplast metabolism. Therefore,in this review, we will focus on the role of apicoplast inmalaria biology and its metabolic regulation through Ca++signaling.
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