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Thuong, Phuong Thien,Hung, Tran Manh,Khoi, Nguyen Minh,Nhung, Hoang Thi My,Chinh, Nguyen Thi,Quy, Nguyen Thi,Jang, Tae Su,Na, MinKyun 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin $A_2$ and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with $IC_{50}$ value of $10.1{\mu}M$. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.
Phuong Thien Thuong,Tran Manh Hung,Nguyen Minh Khoi,Hoang Thi My Nhung,Nguyen Thi Chinh,Nguyen Thi Quy,장태수,나민균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
Four lignans, meso-dihydroguaiaretic acid(DHGA), macelignan, fragransin A2 and nectandrin B,were isolated from the seeds of Myristica fragrans (Vietnamesenutmeg) and investigated for their cytotoxicactivity against eight cancer cell lines. Of these, DHGAexhibited potent cytotoxicity against H358 with IC50 valueof 10.1 lM. In addition, DHGA showed antitumor activityin allogeneic tumor-bearing mice model.