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RISS 인기검색어
- 검색키워드
- 주제어 : SNU miniature pig (검색결과 5 건)
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YEOM, Su-Cheong,KONG, Dae-Young,PARK, Chung-Gyu,LEE, Byeong-Chun,LEE, Wang-Jae Blackwell Publishing Asia 2010 ANIMAL SCIENCE JOURNAL Vol.81 No.2
<P>ABSTRACT</P><P>Seoul National University (SNU) miniature pigs are originated from the Minnesota miniature pig. This study was conducted to investigate the maternal origin of SNU (Minnesota) miniature pigs and their phylogenetic relationships by analyzing the mitochondrial DNA (mtDNA) <I>D-loop</I> (control region) sequence. Two mtDNA <I>D-loop</I> sequences of the SNU miniature pigs were identified. On an unweighted pair-group method with an arithmetic mean (UPGMA) phylogenetic tree analysis, the large white was the pig breed closest to the SNU miniature pig, and the pairwise distance analysis showed the same result. While mtDNA sequences of 4 pig breeds which were used to establish Minnesota miniature pig were not known, our result might be different from the history of the Minnesota miniature pig development. In conclusion, we thought that some haplotypes of the Minnesota miniature pig maternally were originated from the Large white pig, or that wild pigs had similar mtDNA sequences to the Large white pig, and all SNU miniature pigs were derived from this colony.</P>
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Yeom, Su-Cheong,Koo, Ok Jae,Park, Chung-Gyu,Lee, Byeong-Chun,Lee, Wang-Jae The Korean Society of Animal Reproduction 2013 Reproductive & developmental biology Vol.37 No.1
In order to investigate genetic stability and gene expression profile after cloning procedure, two groups of cloned pigs were used for swine leukocyte antigen (SLA) gene nucleotide alteration and microarray analyses. Each group was consist of cloned pigs derived from same cell line (n=3 and 4, respectively). Six SLA loci were analyzed for cDNA sequences and protein translations. In total, 16 SLA alleles were identified and there were no evidence of SLA nucleotide alteration. All SLA sequences and protein translations were identical among the each pig in the same group. On the other hand, microarray assay was performed for profiling gene expression of the cloned pigs. In total, 43,603 genes were analyzed and 2,150~4,300 reliably hybridized spots on the each chip were selected for further analysis. Even though the cloned pigs in the same group had identical genetic background, 18.6~47.3% of analyzed genes were differentially expressed in between each cloned pigs. Furthermore, on gene clustering analysis, some cloned pigs showed abnormal physiological phenotypes such as inflammation, cancer or cardiomyopathy. We assumed that individual environmental adaption, sociality and rank in the pen might have induced these different phenotypes. In conclusion, the results of the present study indicate that SLA locus genes appear to be stable following SCNT. However, gene expressions and phenotypes between cloned pigs derived from the same cell line were not identical even under the same rearing conditions.
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염수정,구옥재,박정규,이병천,이왕재 사단법인 한국동물생명공학회 2013 Reproductive & developmental biology Vol.37 No.1
In order to investigate genetic stability and gene expression profile after cloning procedure, two groups of cloned pigs were used for swine leukocyte antigen (SLA) gene nucleotide alteration and microarray analyses. Each group was consist of cloned pigs derived from same cell line (n=3 and 4, respectively). Six SLA loci were analyzed for cDNA sequences and protein translations. In total, 16 SLA alleles were identified and there were no evidence of SLA nucleotide alteration. All SLA sequences and protein translations were identical among the each pig in the same group. On the other hand, microarray assay was performed for profiling gene expression of the cloned pigs. In total, 43,603 genes were analyzed and 2,150~4,300 reliably hybridized spots on the each chip were selected for further analysis. Even though the cloned pigs in the same group had identical genetic background, 18.6~47.3% of analyzed genes were differentially expressed in between each cloned pigs. Furthermore, on gene clustering analysis, some cloned pigs showed abnormal physiological phenotypes such as inflammation, cancer or cardiomyopathy. We assumed that individual environmental adaption, sociality and rank in the pen might have induced these different phenotypes. In conclusion, the results of the present study indicate that SLA locus genes appear to be stable following SCNT. However, gene expressions and phenotypes between cloned pigs derived from the same cell line were not identical even under the same rearing conditions.
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Ocular biometry of Seoul National University (SNU) miniature pig
Ha young Jang,Seok Jae Lee,Eun Gyeong Yoon,Seong Yong Cho,Dong Hyun Jo,Jeong Hwan Che,Byeong-Cheol Kang,Jeong Hun Kim 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
The pig eye is similar to the human eye in size and structure, containing a cone photoreceptor-dominant visual streak. It makes pigs an important animal species for ocular biomedical studies, including evaluating the safety and efficacy of ocular therapeutics, novel biomaterials, surgical procedures, and implantable materials or devices utilizing advanced in vivo diagnostic techniques. Seoul National University (SNU) miniature pigs (mini-pig) are an important animal resource of Seoul National University Biomedical Center for Animal Resource and Development (BCARD) and are actively used in organ transplantation research. However, further studies on other characteristics were required to be used in various biomedical investigations. Thus ophthalmic features of 6 to 10-month-old three male SNU mini-pigs were characterized using diagnostic modalities including intraocular pressure (IOP) measurement, ultrasonography, fundoscopic imaging, fluorescein angiography (FA), and electroretinography. Mean IOP was 16.47±0.73 mmHg. The optic disc has sharp margins and is normal in color, with a small central cup. Arterioles and venules have normal color and sheen, starting from the center of the disc. There were no abnormalities of FA images such as hyper- or hypo fluorescence and any delay in filling. The amplitudes (μV) of the rod response, mixed rod-cone response, and cone response were 81.73±5.49, 254.60±9.63, and 102.25±9.99. We performed this study as a beginning point to provide the possibility that SNU mini-pig may become a useful animal species for ophthalmological research and to establish the normative reference through the characterization of SNU mini-pig using diagnostic modalities.
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