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인공피부모델과 사람, 돼지 피부의 피부흡수시험 비교 검증 연구
한주희 ( Ju Hee Han ),김시윤 ( C-yoon Kim ),임채형 ( Chae Hyung Lim ),나이랑 ( Yi Rang Na ),김태현 ( Tae Hyoun Kim ),정현 ( Hyun Jung ),석승혁 ( Seung Hyeok Seok ),정초록 ( Cho-rok Jung ),박재학 ( Jae Hak Park ) 한국동물실험대체법학회 2017 동물실험대체법학회지 Vol.11 No.1
This study was carried out in accordance with OECD guidelines on skin absorption test for the comparison of reconstructed human skin models, EFT-306™ and KeraSkinFT™ with human skin and pig skin. Three OECD standard compounds were used for penetration and absorption: Caffeine, benzoic acid and testosterone, all of which differ vastly in their lipophilicity. Reconstructed human skins were more permeable to low lipophilic compounds such as caffeine than human and pig skin. Differences became most obvious with KeraSkinFT™ showing a relatively weak penetration barrier on caffeine. EFT-306™ and KeraSkinFT™ both showed similar penetration patterns in the case of lipophilic compounds, benzoic acid and testosterone compared with human and pig skins. High correlation was observed on the penetration flux between the reconstructed human skin models and human and pig skin, even though different penetration rates existed. The reconstructed human skin models can be regarded as generally useful on lipophilic compounds for in-vitro penetration studies.
플라스틱 가소제인 phthalate에 대한 경피 흡수 특성 연구
김낙주 ( Nack Joo Kim ),오은하 ( Eun Ha Oh ),서한슬 ( Han Seul Suh ),정광보 ( Kwang Bo Chung ),윤철훈 ( Cheol Hun Yoon ) 한국환경분석학회 2013 환경분석과 독성보건 Vol.16 No.1
Phthalate is used in a wide range of consumer goods. It has been the subject of great public concern in recent years. It has attracted the attention of extensive uses of this material and issues regarding its safety have been raised. Phthalate is currently used through direct addition in cosmetic products and indirectly in fragrances. The material is listed in the inventory of ingredients employed as a solvent and vehicle in fragrance and cosmetic products, as well as a plasticizer, denaturant, and film former. In this study, using in vitro from Rat phthalate 3 types of skin permeation were studied using matrix such as ointment, cream and lotion in vitro. The absorption of phthalate diesters [Butyl benzyl Phthalate (BBP), dibutyl phthalate (DBP) and Diisobutyl Phthalate (DIBP)] has been measured in vitro through rat skin. Epidermal membranes were set up in Franz diffusion cells and their permeability to PBS measured to establish the integrity of the skin before the phthalate were applied to the epidermal surface. Absorption rates for each phthalate ester were determined and permeability assessment made to quantify any irreversible alterations in barrier function due to contact with the esters. Types of phthalate in vitro experimental results on DBP > DIBP > BBP quickly appeared in the following order: skin permeation was beneficial to the skin permeation small molecular weight, the difference in chemical structure, such as hydrophilic, because with the partition coefficient and solubility mechanisms and passive diffusion to increase the speed at which transmission is considered. As the esters became more lipophilic and less hydrophilic, the rate of absorption was reduced.