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- 주제어 : Crassostrea hongkongensis (검색결과 2 건)
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Bingna Cai,Peng Wang,Huili Sun,Deke Chen,Hua Chen,Xin Chen,Jianyu Pan 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.4
Chemotherapeutics, including 5-fluorouracil (5-FU), often damage the intestinal mucosal barrier and cause intestinal mucositis (IM). Supplementation with immunoregulatory polysaccharides from Crassostrea hongkongensis has been shown to positively influence the effectiveness and toxicity of 5-FU. Therefore, we studied the effects of oyster polysaccharides on 5-FU-induced intestinal mucosal damage in rats. The C30–60% ethanol-precipitated fraction of polysaccharides promoted IEC-6 cell proliferation and exhibited a maximal effect at a 0.0195 mg/mL concentration. Moreover, treatment with C30–60% polysaccharide-based nutrition formula (OPNF) partially prevented the 5-FU-induced degenerative changes in the histology and ultrastructure of small intestinal mucosa. In addition, the endotoxin level of rats fed with 5-FU and OPNF decreased to the normal control level. Furthermore, the 5-FU-induced increase of proinflammatory cytokine interleukin (IL)-2 and the decrease of anti-inflammatory cytokine IL-10 level in the peripheral blood were significantly attenuated by OPNF administration. In conclusion, Oyster C30–60% polysaccharides can ameliorate 5-FU-induced IM by partially preventing mucosal damage, reducing inflammation, and promoting immunity.
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Xuelin Zhao,Huitong Shi,Hong Yu,Qi Li 한국유전학회 2015 Genes & Genomics Vol.37 No.7
We isolated and characterized a total of 41 polymorphic microsatellite loci in Crassostrea hongkongensis, an oyster restricted to southern China. Loci were screened in 30 wild individuals from southern coastal region in China. The number of alleles per locus ranged from 2 to 18, observed heterozygosity and expected heterozygosity ranged from 0.000–0.867 to 0.066–0.926, respectively. To study the genetic diversity and population structure of this species form 3 locations, such as Xiamen, Zhuhai and Qinzhou, 12 loci were chosen from the 41 loci. The three sample sets displayed different diversity levels and observed heterozygosity ranged from 0 to 0.867. Significant genotype heterogeneity (P\0.001) over most loci indicated that the samples are not drawn from the same gene pool. The pairwise FST values between XM and ZH, and QZ and ZH indicate that there were significant deviations in genetic differentiations for the Hongkong oyster populations from these locations. These new microsatellite loci will facilitate future studies of population structure and investigation of conservation genetics in this species.
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