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RISS 인기검색어
- 검색키워드
- 주제어 : Apolipoproteins · Osteoporosis (검색결과 2 건)
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( Yaprak Engin-ustun ),( Emel Kıyak Caglayan ),( Ayse Yesim Gocmen2 ),( Muhammed Fevzi Polat ) 대한폐경학회 2016 대한폐경학회지 Vol.22 No.2
Objectives: The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis. Methods: The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤ -2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score > -1 were selected as controls (n = 88) and case-matched in a 1:1 ratio based on age (within 2 years) and body mass index (BMI) (within 1.0 kg/m²). ApoM, irisin and chemerin levels were determined by a commercially available enzyme-linked immunosorbent assay (ELISA) kit. Results: There were no significant differences in age, BMI, parity, cholesterol and apoM levels between the two groups. C-reactive protein levels were significantly increased in women with osteoporosis. Serum chemerin levels (240.1 ± 46.1 vs. 261.5 ± 50.8 ng/ mL) were significantly lower in the women with osteoporosis, as compared to the controls (P = 0.004). Serum irisin levels were also decreased in women with osteoporosis (0.7 ± 0.2 vs. 0.8 ± 0.2 ng/mL; P = 0.007). Conclusions: In the present study, osteoporosis was associated with decreased levels of circulating chemerin and irisin. These findings suggested that adipokines might play a role in the pathogenesis of osteoporosis. (J Menopausal Med 2016;22:76-79)
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아포지단백 E 유전자 다형성이 폐경 후 여성 류마티스관절염 환자의 골밀도에 미치는 영향
이상일 ( Sang Il Lee ),박진용 ( Jin Yong Park ),오수진 ( Su Jin Oh ),나영균 ( Young Gyun Na ),정치량 ( Chi Ryang Chung ),최영훈 ( Young Hun Choi ),윤희진 ( Hee Jin Yun ),류완희 ( Wan Hee Yoo ) 대한류마티스학회 2006 대한류마티스학회지 Vol.13 No.4
Objective: To evaluate the relationship between the presence of apolipoprotein E (Apo E) 4 allele and bone mineral density (BMD) and severity of joint destruction in postmenopausal women with rheumatoid arthritis (RA). Methods: Apo E genotypes were analyzed in 113 postmenopausal women who were first diagnosed with RA and had not receiving antiresorptive therapy for osteoporosis at the time of enrollment. BMD was measured using dual-energy X-ray absorptiometry (DEXA), and joint destruction was evaluated on plain radiographs according to Larsen score. The differences in BMD and severity of joint destruction in groups with and without an Apo E4 allele were analyzed in 94 patients with clinical information available. Results: BMD (g/cm2) of the lumbar spine in the Apo E4 (-) group was 0.94±0.16 (n=67), whereas that in the Apo E4 (+) group was 0.87±0.14 (n=27; p=0.049). BMD of the femoral neck and great trochanter in the Apo E4 (-) group was 0.74±0.12 and 0.63±0.11, while that in the Apo E4 (+) group was 0.68±0.11 (p=0.039) and 0.57±0.11 (p=0.008). However, there were no significant differences in Larsen scores and erosive disease (%) between the Apo E4 (+) and Apo E4 (-) groups. Conclusion: The Apo E4 allele is associated with a reduced bone mass in postmenopausal RA patients. Therefore, Apo E4 allele is considered to be an independent risk factor for generalized osteoporosis in postmenopausal RA patients.
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