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RISS 인기검색어
- 검색키워드
- 주제어 : Acanthopanax henryi (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Zhang, Xiao Dan,Liu, Xiang Qian,Kim, Yang Hee,Whang, Wan Kyunn 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5
The aim of this study was to investigate chemical constituents of the leaves of Acanthopanax henryi, and their antioxidant, acetyl cholinesterase inhibitory activities. Caffeoyl quinic acid derivates and flavonoids were obtained from A. henry, through column chromatography technologies, and the content of major constituents was determined by the HPLC-UV method. Anti-oxidant activity of the isolated metabolites was evaluated by free radical scavenging (DPPH, ABTS radicals) and superoxide anion scavenging. The results showed that di-caffeoyl quinic acid derivates had stronger antioxidant activity than positive controls (ascorbic acid, trolox and allopurinol). Acetyl cholinesterase inhibitory activity was estimated on the constituents, among which, quercetin, 4-caffeoyl-quinic acid and 4,5-caffeoyl quinic acid were found to have strong acetyl cholinesterase inhibitory activity with $IC_{50}$ values ranging from 62.6 to $121.9{\mu}M$. The present study showed that some of the tested constituents from the leaves of A. henryi exhibit strong antioxidant and acetyl cholinesterase inhibitory effects. This suggest that the leaves of A. henryi can be used as a new natural complementary source of acetyl cholinesterase inhibitors and anti-oxidant agents, thus being a promising potential complementary source against Alzheimer's disease.
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Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi
KIM, J.H.,LIU, X.Q.,DAI, L.,YOOK, C.S.,LEE, K.T. Elsevier 2014 Chinese journal of natural medicines Vol.12 No.2
Aim: To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. Method: The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide (LPS)-induced nitric oxide, prostaglandin E<SUB>2</SUB>, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages. Results: The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE<SUB>2</SUB>, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase (iNOS) at the protein levels in a concentration-dependent manner. Conclusion: The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation.
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Xiaodan Zhang,Xiang Qian Liu,김영희,황완균 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.5
The aim of this study was to investigatechemical constituents of the leaves of Acanthopanax henryi,and their antioxidant, acetyl cholinesterase inhibitoryactivities. Caffeoyl quinic acid derivates and flavonoidswere obtained from A. henry, through column chromatographytechnologies, and the content of major constituentswas determined by the HPLC–UV method. Anti-oxidantactivity of the isolated metabolites was evaluated by freeradical scavenging (DPPH, ABTS radicals) and superoxideanion scavenging. The results showed that di-caffeoylquinic acid derivates had stronger antioxidant activity thanpositive controls (ascorbic acid, trolox and allopurinol). Acetyl cholinesterase inhibitory activity was estimated onthe constituents, among which, quercetin, 4-caffeoyl-quinicacid and 4,5-caffeoyl quinic acid were found to have strongacetyl cholinesterase inhibitory activity with IC50 valuesranging from 62.6 to 121.9 lM. The present study showedthat some of the tested constituents from the leaves of A. henryi exhibit strong antioxidant and acetyl cholinesteraseinhibitory effects. This suggest that the leaves of A. henryi can be used as a new natural complementary source ofacetyl cholinesterase inhibitors and anti-oxidant agents,thus being a promising potential complementary sourceagainst Alzheimer’s disease.
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