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전영우 ( Young Woo Jeon ),김재연 ( Jae Yun Kim ),박재석 ( Jae Seok Park ),박재만 ( Jae Man Park ),길효욱 ( Hyo Wook Gil ),양종오 ( Jong Oh Yang ),이은영 ( Eun Young Lee ),홍세용 ( Sae Yong Hong ) 대한내과학회 2011 대한내과학회지 Vol.81 No.2
Background/Aims: Calcium channel blockers (CCBs) are anti-hypertensive medications that are used worldwide. CCB overdose has increased in proportion to the use of these drugs. Although amlodipine is the most widely used CCB, many physicians are not familiar with amlodipine overdose. We report the clinical outcome in patients with an intentional amlodipine overdose. Methods: We retrospectively reviewed the medical records of the patients who visited Soonchunhyang University Cheonan Hospital with an amlodipine overdose from January 2002 through December 2010. We recorded the initial vital signs, blood chemistry, electrocardiography, and estimated amount of amlodipine ingested. Results: Nine patients were enrolled, of whom two patients died. Both patients who died had ingested more than 200 mg/m2 of amlodipine, while all of the patients who ingested less than 200 mg/m2 of amlodipine survived. Three patients had blood sugar levels exceeding 200 mg/dL and two of these died despite high-dose insulin therapy in combination with glucose infusion (hyperinsulinemia/euglycemia therapy). Although three patients also took a glimepiride overdose, none had hypoglycemia. The amount of amlodipine ingested relative to the body surfaced area (BSA) was 197.1±92.3 mg/m2 in patients with an abnormal ECG and 58.5±27.1 mg/m2 in patients with a normal ECG. Conclusions: Amlodipine overdose can induce hyperglycemia, resulting in lethal cardiogenic shock owing to the decreased calcium influx, inappropriate energy production, and weakened inotropic effect. Therefore, amlodipine-induced hyperglycemia indicates a poor prognosis. (Korean J Med 2011;81:208-214)
장기간 Amlodipine 복용 후 발생한 심한 잇몸 과증식
이성진 ( Sung Jin Lee ),정영국 ( Young Kuk Chung ),이해림 ( Hae Lim Lee ),최수진 ( Su Jin Choi ),조성연 ( Sung Yeon Cho ),최현주 ( Hyun Joo Choi ),김형욱 ( Hyung Wook Kim ) 대한내과학회 2012 대한내과학회지 Vol.82 No.5
Amlodipine is one of the most commonly used calcium-channel blockers for the management of hypertension in Korea. Gingival overgrowth is an infrequent complication in patients receiving amlodipine treatment. A 52-year-old man on an amlodipine regimen of 10 mg/day for 25 months sought medical attention because of gradually progressive gingival enlargement. Examination of the oral cavity revealed severe gingival overgrowth. We stopped the amlodipine treatment and recommended the maintenance of good oral hygiene and a gingivectomy. Histological findings of the gingivectomy were typical of drug-induced gingival overgrowth, including epithelial thickening with proliferation, acanthosis with elongated rete ridges, and focal parakeratosis. A marked reduction in gingival overgrowth was evident 1 month after the gingivectomy and cessation of amlodipine. This report describes the case of a 52-year-old man who developed severe and histologically confirmed amlodipine-induced gingival overgrowth. (Korean J Med 2012;82:623-627)
윤인상 ( Yun In Sang ),이남호 ( Lee Nam Ho ),최승혁 ( Choe Seung Hyeog ),고진석 ( Go Jin Seog ),박동양 ( Park Dong Yang ),김대성 ( Kim Dae Seong ),남대익 ( Nam Dae Ig ) 대한내과학회 2003 대한내과학회지 Vol.64 No.6
Calcium channel blockers are used to treat hypertension. Unwanted side effects associated with calcium channel blockers are facial flushing, headache, palpitation, dizziness, peripheral edema, constipation, indigestion, nausea, gingival hyperplasia, facia