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( Jian Ping Li ),( Yu Li Lin ),( Hong Qin Zhuang ),( Zi Chun Hua ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.9
Urokinase (uPA) and its receptor (uPAR) play an important role in tumor growth and metastasis. Targeting the excessive activation of this system as well as the proliferation of the tumor vascular endothelial cell would be expected to prevent tumor neovasculature and halt the tumor development. In this regard, the amino-terminal fragment (ATF) of urokinase has been confirmed as effective to inhibit the proliferation, migration, and invasiveness of cancer cells via interrupting the interaction of uPA and uPAR. Previous studies indicated that ATF expressed in Escherichia coli was mainly contained in inclusion bodies and also lacked posttranslational modifications. In this study, the biologically active and soluble ATF was cloned and expressed in Pichia pastoris. The recombinant protein was purified to be homogenous and confirmed to be biologically active. The yield of the active ATF was about 30 mg/l of the P. pastoris culture medium. The recombinant ATF (rATF) could efficiently inhibit angiogenesis, endothelial cell migration, and tumor cell invasion in vitro. Furthermore, it could inhibit in vivo xenograft tumor growth and prolong the survival of tumor-bearing mice significantly by competing with uPA for binding to cell surfaces. Therefore, P. pastoris is a highly efficient and cost-effective expression system for large-scale production of biologically active rATFs for potential therapeutic application.
Two New Monoterpene Alkaloid Derivatives from the Roots of Incarvillea arguta
Jian Jun Fu,Hui Zi Jin,Jiang Jiang Qin,Qi Zeng,Ying Huang,Wei Dong Zhang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.2
Two new monoterpene alkaloid derivatives, incargutosines C (1) and D (2), together with a known compound, argutine A (3) have been isolated from the roots of Incarvillea arguta Royle. The structures of 1 and 2 were established on the basis of 1D and 2D NMR spectroscopic analysis, while the absolute configurations of 1 and 2 were determined by a synthetic method. In addition, the cytotoxicity of 3 was evaluated using four tumor cell lines, A549, LOVO, 6TCEM, and MDA-MB-435 (MDA) by the MTT assay.
A New Triterpenoid from Brucea javanica
Jian Hua Liu,Jiang Jiang Qin,Hui Zi Jin,Xiao Jia Hu,Ming Chen,Yun Heng Shen,Shi Kai Yan,Wei Dong Zhang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.5
A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-α-L-arabinopyranosylpregn- 5-ene-3β,20-diol (8), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.
Yuan, Zi-Xu,Ma, Teng-Hui,Zhong, Qing-Hua,Wang, Huai-Ming,Yu, Xi-Hu,Qin, Qi-Yuan,Chu, Li-Li,Wang, Lei,Wang, Jian-Ping Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Radiation proctitis is a common complication after radiotherapy for pelvic malignant tumors. This study was conducted to assess the efficacy of novel almagate enemas in hemorrhagic chronic radiation proctitis (CRP) and evaluate risk factors related to rectal deep ulcer or fistula secondary to CRP. All patients underwent a colonoscopy to confirm the diagnosis of CRP and symptoms were graded. Typical endoscopic and pathological images, risk factors, and quality of life were also recorded. A total of 59 patients were enrolled. Gynecological cancers composed 93.1% of the primary malignancies. Complete or obvious reduction of bleeding was observed in 90% (53/59) patients after almagate enema. The mean score of bleeding improved from 2.17 to 0.83 (P<0.001) after the enemas. The mean response time was 12 days. No adverse effects were found. Moreover, long-term successful rate in controlling bleeding was 69% and the quality of life was dramatically improved (P=0.001). The efficacy was equivalent to rectal sucralfate, but the almagate with its antacid properties acted more rapidly than sucralfate. Furthermore, we firstly found that moderate to severe anemia was the risk factor of CRP patients who developed rectal deep ulcer or fistulas (P= 0.015). We also found abnormal hyaline-like thick wall vessels, which revealed endarteritis obliterans and the fibrosis underlying this disease. These findings indicate that almagate enema is a novel effective, rapid and well-tolerated method for hemorrhagic CRP. Moderate to severe anemia is a risk factor for deep ulceration or fistula.
A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb
Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10
A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.
Ji-Ying Shi,Fei Xue,Zi-Jian Qin,Wen Zhang,Le-Tao Ling,Ting Yang 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1
Conventional maximum power point tracking (MPPT) methods are ineffective under partially shaded conditions because multiple local maximum can be exhibited on power–voltage characteristic curve. This study proposes an improved cuckoo search (ICS) MPPT method after investigating the cuckoo search (CS) algorithm applied in solving multiple MPPT. The algorithm eliminates the random step in the original CS algorithm, and the conception of low-power, high-power, normal and marked zones are introduced. The adaptive step adjustment is also realized according to the different stages of the nest position. This algorithm adopts the large step in low-power and marked zones to reduce search time, and a small step in high-power zone is used to improve search accuracy. Finally, simulation and experiment results indicate that the promoted ICS algorithm can immediately and accurately track the global maximum under partially shaded conditions, and the array output efficiency can be improved.
Shi, Ji-Ying,Xue, Fei,Qin, Zi-Jian,Zhang, Wen,Ling, Le-Tao,Yang, Ting The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1
Conventional maximum power point tracking (MPPT) methods are ineffective under partially shaded conditions because multiple local maximum can be exhibited on power-voltage characteristic curve. This study proposes an improved cuckoo search (ICS) MPPT method after investigating the cuckoo search (CS) algorithm applied in solving multiple MPPT. The algorithm eliminates the random step in the original CS algorithm, and the conception of low-power, high-power, normal and marked zones are introduced. The adaptive step adjustment is also realized according to the different stages of the nest position. This algorithm adopts the large step in low-power and marked zones to reduce search time, and a small step in high-power zone is used to improve search accuracy. Finally, simulation and experiment results indicate that the promoted ICS algorithm can immediately and accurately track the global maximum under partially shaded conditions, and the array output efficiency can be improved.
Ji-Ying Shi,Fei Xue,Le-Tao Ling,Xiao-Fei Li,Zi-Jian Qin,Ya-Jing Li,Ting Yang 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.2
Under partial shading conditions (PSCs), multiple maximums may be exhibited on the P-U curve of string inverter photovoltaic (PV) systems. Under such conditions, heuristic methods are invalid for extracting a global maximum power point (GMPP); intelligent algorithms are time-consuming; and model-based methods are complex and costly. To overcome these shortcomings, a novel hybrid MPPT (MPF-IP&O) based on a model-based peak forecasting (MPF) method and an improved perturbation and observation (IP&O) method is proposed. The MPF considers the influence of temperature and does not require solar radiation measurements. In addition, it can forecast all of the peak values of the PV string without complex computation under PSCs, and it can determine the candidate GMPP after a comparison. Hence, the MPF narrows the searching range tremendously and accelerates the convergence to the GMPP. Additionally, the IP&O with a successive approximation strategy searches for the real GMPP in the neighborhood of the candidate one, which can significantly enhance the tracking efficiency. Finally, simulation and experiment results show that the proposed method has a higher tracking speed and accuracy than the perturbation and observation (P&O) and particle swarm optimization (PSO) methods under PSCs.
Shi, Ji-Ying,Xue, Fei,Ling, Le-Tao,Li, Xiao-Fei,Qin, Zi-Jian,Li, Ya-Jing,Yang, Ting The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.2
Under partial shading conditions (PSCs), multiple maximums may be exhibited on the P-U curve of string inverter photovoltaic (PV) systems. Under such conditions, heuristic methods are invalid for extracting a global maximum power point (GMPP); intelligent algorithms are time-consuming; and model-based methods are complex and costly. To overcome these shortcomings, a novel hybrid MPPT (MPF-IP&O) based on a model-based peak forecasting (MPF) method and an improved perturbation and observation (IP&O) method is proposed. The MPF considers the influence of temperature and does not require solar radiation measurements. In addition, it can forecast all of the peak values of the PV string without complex computation under PSCs, and it can determine the candidate GMPP after a comparison. Hence, the MPF narrows the searching range tremendously and accelerates the convergence to the GMPP. Additionally, the IP&O with a successive approximation strategy searches for the real GMPP in the neighborhood of the candidate one, which can significantly enhance the tracking efficiency. Finally, simulation and experiment results show that the proposed method has a higher tracking speed and accuracy than the perturbation and observation (P&O) and particle swarm optimization (PSO) methods under PSCs.
Ji-Ying Shi,Deng-Yu Zhang,Le-Tao Ling,Fei Xue,Ya-Jing Li,Zi-Jian Qin,Ting Yang 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.3
This paper presents a dual-algorithm search method (GWO-GSO) combining grey wolf optimization (GWO) and golden-section optimization (GSO) to realize maximum power point tracking (MPPT) for photovoltaic (PV) systems. First, a modified grey wolf optimization (MGWO) is activated for the global search. In conventional GWO, wolf leaders possess the same impact on decision-making. In this paper, the decision weights of wolf leaders are automatically adjusted with hunting progression, which is conducive to accelerating hunting. At the later stage, the algorithm is switched to GSO for the local search, which play a critical role in avoiding unnecessary search and reducing the tracking time. Additionally, a novel restart judgment based on the quasi-slope of the power-voltage curve is introduced to enhance the reliability of MPPT systems. Simulation and experiment results demonstrate that the proposed algorithm can track the global maximum power point (MPP) swiftly and reliably with higher accuracy under various conditions.