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Fan Dong Kong,Li Man Zhou,Qing Yun Ma,Sheng Zhuo Huang,Pei Wang,Hao Fu Dai,You-Xing Zhao 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.1
Three new compounds named penicitor A,aculene E and penicitor B, as well as four known compounds,were isolated from the fermentation broth ofPenicillium sp. SCS-KFD08 associated with a marineanimal Sipunculus nudus from the Haikou bay of China. Their planar structures and absolute configurations wereunambiguously elucidated by spectroscopic data, Mosher’smethod, CD spectrum analysis along with quantumECD calculation. Among them, compounds 2–7 showedquorum sensing inhibitory activity against Chromobacteriumviolaceum CV026, and could significantly reduceviolacein production in N-hexanoyl-l-homoserine lactone(C6-HSL) induced C. violaceum CV026 cultures at subinhibitoryconcentrations.
Transcriptomics and proteomics analysis of Aβ (1-42)-induced neurotoxicity
Zhonghao Su,Zhuo Dong,Chunxia Guo,Ying Xu,Shuijin Shao,Zhenxia Qin 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3
Backgrounds: β-Amyloid (Aβ) is a principal constituent of senile plaques in Alzheimer’s disease (AD) and induces neuronal cell death. The molecular mechanism of how Aβ evokes neuronal cell death remains complicated, which were investigated in the present study. Methods: Using the human neuroblastoma cell line SHSY5Y, we investigated the neurotoxic effects of human β-Amyloid 1-42 (Aβ1-42) aggregates on gene expression profile and protein expression profile by using the Agilent GeneChip Human 1A (V2) Oligo MicroArray, Quantitative Real-time PCR, PF-2D and Western blot analysis. Results: Our results show that Aβ1-42 specifically influences gene and protein expression such as EGR1, eIF5A, PDE8A, ERp57 and ERp5 in pathways associated with apoptotic process, protein translation, cAMP catabolic process and response to endoplasmic reticulum stress. Conclusion: Although Genes with significant changes in transcriptomic analysis matched very few of the proteins identified in proteomics analysis, our findings will strengthen our knowledge concerning the molecular mechanisms underlying AD.