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- 저자 : Zhu Xinglong (검색결과 3 건)
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Liver Organoids: Formation Strategies and Biomedical Applications
Zhu Xinglong,Zhang Bingqi,He Yuting,Bao Ji 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.4
The liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models. Traditional 2D cell lines do not represent the complex three-dimensional tissue architecture whereas animal models are limited by inter-species differences. These shortcomings limit understanding of liver biology and diseases. Liver organoid technology is effective in elucidating structural and physiological characteristics and basic tissue-level functions of liver tissue. In this review, formation strategies and a wide range of applications in biomedicine of liver organoid are summarized. Liver organoids are derived from single type cell culture, such as induced pluripotent stem cells (iPSCs), adult stem cells, primary hepatocytes, and primary cholangiocytes and multi-type cells co-culture, such as iPSC-derived hepatic endoderm cells co-cultured with mesenchymal stem cells and umbilical cord-derived endothelial cells. In vitro studies report that liver organoids are a promising model for regenerative medicine, organogenesis, liver regeneration, disease modelling, drug screening and personalized treatment. Liver organoids are a promising in vitro model for basic research and for development of clinical therapeutic interventions for hepatopathy.
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Effect of 3C-SiC Intermediate Layer in GaN-Based Light Emitting Diodes Grown on Si(111) Substrate
Youhua Zhu,Meiyu Wang,Yi Li,Shuxin Tan,Honghai Deng,Xinglong Guo,Haihong Yin,Takashi Egawa 대한금속·재료학회 2017 ELECTRONIC MATERIALS LETTERS Vol.13 No.2
GaN-based light emitting diodes (LEDs) have been grown by metalorganicchemical vapor deposition on Si(111) substrate with and without3C-SiC intermediate layer (IL). Structural property has been characterizedby means of atomic force microscope, X-ray diffraction, andtransmission electron microscope measurements. It has been revealedthat a significant improvement in crystalline quality of GaN and superlatticeepitaxial layers can be achieved by using 3C-SiC as IL. Regardingof electrical and optical characteristics, it is clearly observed that theLEDs with its IL have a smaller leakage current and higher light outputpower comparing with the LEDs without IL. The better performance ofLEDs using 3C-SiC IL can be contributed to both of the improvementsin epitaxial layers quality and light extraction efficiency. As aconsequence, in terms of optical property, a double enhancement of thelight output power and external quantum efficiency has been realized.
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Reliability assessment method based on the meta-action unit for complex mechanical system
Xiao Zhu,Yan Ran,Xinglong Li 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3
In this paper, a functionality unit named as meta-action unit (MAU) is proposed to correlate the system function with the part actions and assess reliability of mechanical system. Firstly, the function of system is decomposed into multiple MAUs by function-movementaction (FMA). Then, the lifetime of MAU is fitted by Weibull distribution, and its parameters are estimated by support vector regression (SVR). In addition, taking the distributions of MAU as marginal distributions, the lifetime distribution of mechanical system is constructed by copula function to assess system reliability, and its parameters are estimated using the maximum likelihood estimator (MLE). Further, the reliability assessment accuracy based on MAU is compared with that from traditional method based on mechanical part failure modes. Finally, the reliability assessment of the indexing turntable (IT) is performed as an example to illustrate the feasibility and reasonability of the proposed method.
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